Dr. William Hahn, MD

• Medical Oncology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Whitehead Inst

  Fellowship Hospital, 2001

• Dana-farber Cancer Institute

  Fellowship Hospital, 1999

• Harvard University

  Fellowship Hospital, 1999

• Massachusetts General Hospital

  Residency Hospital, 1996

• Massachusetts General Hospital

  Internship Hospital, 1995

• Harvard Medical School

  Medical School, 1994

• ARID1B is a specific vulnerability inARID1A-mutant cancers, 2014-02-23

• Identification of an "Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-targeted Therapy, 2015-11-18

• Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets, 2019-12-20

• Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting, 2016-06-03

• CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer, 2019-11-19

• Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 lysine 27 trimethylation, 2014-04-20

• Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex, 2022-07-13

• Defining a Cancer Dependency Map, 2017-07-27

• BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors, 2019-04-23

• Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer, 2011-02-20

• Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway, 2017-07-05

• Structural Basis of PP2A Inhibition by Small t Antigen, 2007-07-03

• The tyrosine kinase adaptor protein FRS2 is oncogenic and amplified in high-grade serous ovarian cancer, 2014-11-03

• Small-molecule and CRISPR screening converge to reveal RTK dependencies in pediatric rhabdoid tumors, 2019-08-27

• PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length, 2014-05-22

• TRAF2 is an NF-?B activating oncogene in epithelial cancers, 2013-12-23

• Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine, 2018-06-14

• Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKe promotes cell transformation, 2009-05-14

• Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models, 2018-05-22

• MTAPdeletion confers enhanced dependency on the arginine methyltransferase PRMT5 in human cancer cells, 2016-02-11

• An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells, 2010-03-16

• Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges, 2011-09-01

• SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis, 2009-07-21

• Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit, 2014-01-20

• PAK1is a breast cancer oncogene that coordinately activates MAPK and MET signaling, 2011-11-21

• Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer, 2021-12-09

• Discovery of a selective inhibitor of Doublecortin Like Kinase 1, 2020-04-06

• Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer targetID4, 2012-08-15

• MYC activity mitigates response to rapamycin in prostate cancer through 4EBP1-mediated inhibition of autophagy, 2009-09-22

• Proteomic and Genetic Approaches Identify Syk as an AML Target, 2009-10-06

• Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects, 2021-12-20

• Initial genome sequencing and analysis of multiple myeloma, 2011-03-24

• The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth, 2008-04-16

• Prmt1-mediated translation regulation is a crucial vulnerability of cancer, 2017-06-27

• Renal medullary carcinomas depend uponSMARCB1loss and are sensitive to proteasome inhibition, 2019-03-12

• The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis, 2015-10-12

• Profiling Critical Cancer Gene Mutations in Clinical Tumor Samples, 2009-11-18

• A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer, 2022-02-22

• Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer, 2021-03-30

• PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival, 2010-07-23

• Phosphate dysregulation via the XPR1:KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer, 2022-04-18

• A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer, 2015-03-09

• Analysis ofFusobacteriumpersistence and antibiotic response in colorectal cancer, 2017-11-23

• KRAS and YAP1 converge to regulate EMT and tumor survival, 2014-06-19

• PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA, 2017-04-27

• Systematic interrogation of 3q26 identifiesTLOC1andSKILas cancer drivers, 2013-06-13

• Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells, 2017-10-30

• MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma, 2012-05-15

• High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing, 2011-11-07

• ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition, 2017-02-07

• Amplification ofCRKLinduces transformation and EGFR inhibitor resistance in human non small cell lung cancers, 2011-10-17

• Haplotype-resolved germline and somatic alterations in renal medullary carcinomas, 2021-07-14

• Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q, 2020-12-15

• Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States, 2017-08-23

• Biologically informed deep neural network for prostate cancer discovery, 2021-09-22

• Castration resistance in prostate cancer is mediated by the kinase NEK6, 2016-11-29

• TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma, 2019-05-20

• HIF1A employs CDK8-Mediator to stimulate RNAPII elongation, 2013-06-06

• Revving the throttle on an oncogene: CDK8 takes the driver seat, 2009-10-06

• Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in ß-Catenin-Active Cancers, 2016-09-28

• IKKe-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex, 2013-02-28

• Selective gene dependencies inMYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry, 2018-08-20

• Genomic sequencing of meningiomas identifies oncogenicSMOandAKT1mutations, 2013-01-20

• Emerging roles for the non-canonical IKKs in cancer, 2010-11-01

• Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells, 2018-12-21

• An oncogenic role forETV1in melanoma, 2010-02-16

• RMRPIs a Non-Coding RNA Essential for Early Murine Development, 2011-10-19

• Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins, 2021-01-05

• Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens, 2018-05-16

• MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors, 2019-02-12

• SWI/SNF mutant cancers depend upon catalytic and non-catalytic activity of EZH2, 2015-11-09

• COT/MAP3K8drives resistance to RAF inhibition through MAP kinase pathway reactivation, 2010-11-24

• Integrative analysis of 1q23.3 copy number gain in metastatic urothelial carcinoma, 2014-01-31

• Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism, 2020-03-24

• RNF43 is frequently mutated in colorectal and endometrial cancers, 2014-10-26

• FGFR2Extracellular Domain In-Frame Deletions are Therapeutically Targetable Genomic Alterations that Function as Oncogenic Drivers in Cholangiocarcinoma, 2021-04-29

• An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and NF-?B, 2010-02-14

• CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies, 2022-05-12

• Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies, 2014-09-30

• Colorectal Cancers from Distinct Ancestral Populations Show Variations inBRAFMutation Frequency, 2013-09-16

• Systematic functional interrogation of rare cancer variants identifies oncogenic alleles, 2016-05-04

• Global computational alignment of tumor and cell line transcriptional profiles, 2021-01-04

• Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells, 2022-04-01

• CDK8 is a colorectal cancer oncogene that regulates ß-catenin activity, 2008-09-14

• Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity, 2023-02-03

• Organoid modeling of the tumor immune microenvironment, 2018-12-13

• An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer, 2013-12-09

• AKT-independent signaling downstream of oncogenicPIK3CAmutations in human cancer, 2009-07-07

• Author Correction: BRD9 defines a SWI/SNF sub-complex and constitutes a specific vulnerability in malignant rhabdoid tumors, 2019-09-26

• Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development, 2008-04-08

• PRKACA Mediates Resistance to HER2-Targeted Therapy in Breast Cancer Cells and Restores Anti-Apoptotic Signaling, 2014-06-09

• Mutational processes shape the landscape ofTP53mutations in human cancer, 2018-09-17

• Mapping the landscape of genetic dependencies in chordoma, 2023-04-06

• Systematic RNA interference reveals that oncogenicKRAS-driven cancers require TBK1, 2009-10-21

• PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma, 2010-05-18

• Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers, 2019-10-01

• High Throughput Interrogation of Somatic Mutations in High Grade Serous Cancer of the Ovary, 2011-09-08

• CDK8 Expression in 470 Colorectal Cancers in Relation to ß-Catenin Activation, Other Molecular Alterations and Patient Survival, 2010-06-15

• CK1e Is Required for Breast Cancers Dependent on ß-Catenin Activity, 2010-02-01

• The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling, 2013-06-02

• Association of Alterations in Main Driver Genes with Outcomes of Patients with Resected Pancreatic Ductal Adenocarcinoma, 2018-03-08

• Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer, 2018-06-28

• A prostatic intraepithelial neoplasia-dependent p27kip1checkpoint induces senescence, inhibits cell proliferation and cancer progression, 2008-08-12

• A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines, 2017-10-04

• A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors, 2014-04-25

• Synthetic Lethal Vulnerabilities inKRAS-mutant Cancers, 2018-08-01

• Analysis of tumor- and stroma-supplied proteolytic networks reveals a brain metastasis-promoting role for cathepsin S, 2014-08-03

• Structure and ubiquitination-dependent activation of Tank-Binding Kinase 1, 2013-02-28

• Going beyond genetics to discover cancer targets, 2017-05-22

• Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas, 2014-01-12

• iRGD-guided tumor penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer, 2018-08-10

• Oncogenic Signaling Adaptor Proteins, 2015-09-12

• Analysis of the 10q11 Cancer Risk Locus ImplicatesMSMBandNCOA4in Human Prostate Tumorigenesis, 2010-11-11

• Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma, 2019-06-03

• MCL1 and DEDD promote urothelial carcinoma progression, 2019-02-18

• YAP1 and PRDM14 converge to promote cell survival and tumorigenesis, 2022-01-05

• PME-1 protects ERK pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma, 2009-03-17

• Suppression of hPOT1 in diploid human cells results in an hTERT dependant alteration of telomere length dynamics, 2009-01-26

• Genome-wide interrogation of human cancers identifies EGLN1 dependency in clear cell ovarian cancers, 2019-03-21

• BET bromodomain inhibition as a therapeutic strategy to target c-Myc, 2011-09-01

• A ubiquitination cascade regulating the integrated stress response and survival in carcinomas, 2023-03-01

• A somatically acquired enhancer of the androgen receptor is a noncoding driver in advanced prostate cancer, 2018-06-14

• Identification of PP2A complexes and pathways involved in cell transformation, 2010-12-15

• Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis, 2018-08-02

• A public genome-scale lentiviral expression library of human ORFs, 2011-06-26

• Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase, 2009-11-06

• Next-generation characterization of the Cancer Cell Line Encyclopedia, 2019-05-08

• Analysis and Comparison of Somatic Mutations in Paired Primary and Recurrent Epithelial Ovarian Cancer Samples, 2014-06-17

• Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer, 2018-07-02

• Integrated genetic and pharmacologic interrogation of rare cancers, 2016-06-22

• Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal, 2023-08-23

• Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma, 2018-07-30

• A First-Generation Pediatric Cancer Dependency Map, 2021-03-22

• Small-molecule targeting of brachyury transcription factor addiction in chordoma, 2019-01-21

• Massively parallel sequencing of formalin-fixed paraffin-embedded tissues, 2012-10-01

• ß-catenin driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis, 2012-12-13

• Genomic sequencing of colorectal adenocarcinomas identifies a recurrentVTI1A-TCF7L2fusion, 2011-09-04

• ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor initiating cell state, 2014-01-16

• An Atlas of Variant Effects to understand the genome at nucleotide resolution, 2023-07-03

• Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma, 2015-07-01

• Genomic insights into WNT/ß-catenin signaling, 2013-12-20

• Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration, 2018-11-02

• An RNA dependent RNA polymerase formed by hTERT and the RNase MRP RNA, 2009-08-23

• ATM Loss Confers Greater Sensitivity to ATR Inhibition than PARP Inhibition in Prostate Cancer, 2020-03-03

• A dominant-negative effect drives selection ofTP53missense mutations in myeloid malignancies, 2019-08-09

• Cancer vulnerabilities unveiled by genomic loss, 2012-08-17

• Whole exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer, 2014-04-20

• Therapeutic Implications of GIPC1 Silencing in Cancer, 2010-12-30

• Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix, 2013-08-23

• Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor, 2017-09-29

• SOX2Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas, 2009-10-04

• Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants, 2005-10-04

• Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation - Rationale, methods and preliminary results from a Sino-American collaboration?, 2010-11-22

• Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition, 2021-06-29

• Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression, 2017-05-23

• Functional analysis of single cells identifies a rare subset of circulating tumor cells with malignant traits†, 2014-02-13

• BRAF Activation Initiates but Does Not Maintain Invasive Prostate Adenocarcinoma, 2008-12-16

• The Landscape of Cancer Cell Line Metabolism, 2019-05-08

• SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization, 2021-07-27

• Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway, 2012-07-19

• An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer, 2018-07-30

• An expanded universe of cancer targets, 2021-03-04

• VRK1 as a synthetic lethal target inVRK2promoter-methylated cancers of the nervous system, 2022-10-10

• Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine, 2020-07-06

• Deubiquitinases maintain protein homeostasis and survival of cancer cells upon glutathione depletion, 2019-02-21

• Sparse dictionary learning recovers pleiotropy from human cell fitness screens, 2022-01-31

• NetSig: network-based discovery from cancer genomes, 2017-12-04