Dr. Timothy Cloughesy, MD

• Neurology

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Memorial Sloan Kettering

  Fellowship Hospital, 1992

• University Of California-los Angeles

  Residency Hospital, 1991

• Maricopa Medical Center

  Internship Hospital, 1988

• Tulane University School Of Medicine

  Medical School, 1987

• Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients, 2015-10-27

• Dendritic Cell Vaccination in Conjunction with a TLR Agonist Polarizes Interferon Immune Responses in Malignant Glioma Patients, 2023-09-12

• Radiographic Response Assessment Strategies for Early-Phase Brain Trials in Complex Tumor Types and Drug Combinations: from Digital "Flipbooks” to Control Systems Theory, 2022-04-22

• Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma, 2015-04-09

• Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug, 2021-11-02

• Protective Properties of Radio-Chemoresistant Glioblastoma Stem Cell Clones Are Associated with Metabolic Adaptation to Reduced Glucose Dependence, 2013-11-18

• Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling, 2019-07-11

• Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age, 2008-10-21

• Increased epithelial membrane protein 2 expression in glioblastoma after treatment with bevacizumab, 2020-09-08

• Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide, 2015-11-06

• Discriminating Survival Outcomes in Patients with Glioblastoma Using a Simulation-Based, Patient-Specific Response Metric, 2013-01-23

• D-2-Hydroxyglutarate is Necessary and Sufficient for Isocitrate Dehydrogenase 1 Mutant-inducedMIR148APromoter Methylation, 2018-03-15

• Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas, 2020-10-26

• Association between tumor acidity and hypervascularity within human gliomas using pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and dynamic susceptibility contrast (DSC) perfusion MRI at 3T, 2019-05-16

• Simultaneous pH- and oxygen-sensitive MRI of human gliomas at 3T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echoplanar imaging (CEST-SAGE-EPI), 2018-04-06

• Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells, 2011-10-19

• mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT, 2017-06-22

• Hypervascular tumor volume estimated by comparison to a large-scale cerebral blood volume radiographic atlas predicts survival in recurrent glioblastoma treated with bevacizumab, 2014-11-14

• Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma, 2018-06-29

• 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling, 2015-07-16

• Imaging biomarkers for antiangiogenic therapy in malignant gliomas, 2013-12-24

• Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry, 2019-02-26

• EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer, 2013-05-23

• Maximum uptake and hypermetabolic volume of18F-FDOPA PET estimate molecular status and overall survival in low-grade gliomas: a PET and MRI study, 2021-02-20

• Author Correction: Federated learning enables big data for rare cancer boundary detection, 2023-01-26

• An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers, 2016-10-13

• Longitudinal Patterns in Clinical and Imaging Measurements Predict Residual Survival in Glioblastoma Patients, 2018-09-26

• Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients, 2013-01-16

• Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI, 2022-01-20

• Glioblastoma Clinical Trials: Current Landscape and Opportunities for Improvement, 2022-02-15

• The Future Glioblastoma Clinical Trials Landscape: Early Phase 0, Window of Opportunity, and Adaptive Phase I-III Studies, 2023-07-04

• Therapeutic response assessment of high-grade gliomas during early phase drug development in the era of molecular and immunotherapies, 2021-07-22

• Non-invasive detection of 2-hydroxyglutarate and other metabolites inIDH1mutant glioma patients using magnetic resonance spectroscopy, 2011-10-21

• Rate of change in maximum18F-FDOPA PET uptake and non-enhancing tumor volume predict malignant transformation and overall survival in low-grade gliomas, 2020-01-24

• Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas, 2023-06-09

• Characterization of Cognitive Function in Survivors of Diffuse Gliomas Using Morphometric Correlation Networks, 2022-05-26

• Phase 1 Trial of Vocimagene Amiretrorepvec and 5-Fluorocytosine for Recurrent High Grade Glioma, 2016-06-01

• Growth Factors and Targeted Therapy for Malignant Glioma Patients: Lessons Learned and the Road Ahead, 2009-05-15

• Federated learning enables big data for rare cancer boundary detection, 2022-12-05

• Decorin expression is associated with predictive diffusion MR phenotypes of anti-VEGF efficacy in glioblastoma, 2020-09-09

• Characterization of cognitive function in survivors of diffuse gliomas using resting-state functional MRI (rs-fMRI), 2021-08-05

• Diffusion MRI Changes in the Anterior Subventricular Zone Following Chemoradiation in Glioblastoma with Posterior Ventricular Involvement, 2020-04-01

• Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial, 2023-05-15

• Nonlinear distortion correction of diffusion MR images improves quantitative DTI measurements in glioblastoma, 2013-12-07

• Modified Criteria for Radiographic Response Assessment in Glioblastoma Clinical Trials, 2017-01-20

• 18F-FDOPA PET and MRI characteristics correlate with degree of malignancy and predict survival in treatment-naive gliomas: a cross-sectional study, 2018-04-20

• Multi-Parametric Radiomic Model to Predict 1p/19q Co-Deletion in Patients with IDH-1 Mutant Glioma: Added Value to the T2-FLAIR Mismatch Sign, 2023-02-07

• Preferential tumor localization in relation to18F-FDOPA uptake for lower-grade gliomas, 2021-03-11

• pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST- EPI) as a potential early biomarker for bevacizumab failure in recurrent glioblastoma, 2019-02-26

• Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma, 2019-02-11

• Relapse patterns and radiation dose exposure in IDH wild-type glioblastoma at first radiographic recurrence following chemoradiation, 2022-09-02

• Paradoxical Association Between Relative Cerebral Blood Volume Dynamics Following Chemoradiation and Increased Progression-Free Survival in Newly Diagnosed IDH Wild-Type MGMT Promoter Methylated Glioblastoma With Measurable Disease, 2022-03-08

• Tumor suppressive miR-148a is silenced by CpG island hypermethylation inIDH1mutant gliomas, 2014-09-15

• Multi-parametric MR-PET imaging predicts pharmacokinetics and clinical response to GDC-0084 in patients with recurrent high-grade glioma, 2020-04-08

• Diffusion MRI phenotypes predict overall survival benefit from anti-VEGF monotherapy in recurrent glioblastoma: Converging evidence from phase II trials, 2017-06-27

• Fyn and Src are Effectors of Oncogenic EGFR Signaling in Glioblastoma Patients, 2009-08-18

• A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE), 2019-12-07

• Report of safety of pulse dosing of lapatinib with temozolomide and radiation therapy for newly-diagnosed glioblastoma in a pilot phase II study, 2017-07-01

• Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastoma, 2013-01-24

• Will Kinase Inhibitors Make it as Glioblastoma Drugs?, 2013-09-12

• Multiparametric MR-PET measurements in hypermetabolic regions reflect differences in molecular status and tumor grade in treatment-naive diffuse gliomas, 2020-09-14

• Mechanisms of resistance to EGFR inhibition reveal metabolic vulnerabilities in human GBM, 2019-07-03

• Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET, 2021-03-10

• Short-interval estimation of proliferation rate using serial diffusion MRI predicts progression-free survival in newly diagnosed glioblastoma treated with radiochemotherapy, 2014-01-07