Dr. Steven Lin, MD

• Radiation Oncology

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• University Of California, Irvine School Of Medicine

  Medical School, 2004

• Severe Lymphopenia During Neoadjuvant Chemoradiation for Esophageal Cancer: A Propensity Matched Analysis of the Relative Risk of Proton versus Photon-Based Radiation Therapy, 2017-12-14

• Possible molecular mechanisms underlying the development of atherosclerosis in cancer survivors, 2023-06-02

• A High Content Clonogenic Survival Drug Screen Identifies MEK Inhibitors as Potent Radiation Sensitizers for KRAS Mutant Non-Small Cell Lung Cancer, 2014-06-26

• On target methods to induce abscopal phenomenon for Off-Target effects: From happenstance to happenings, 2022-11-21

• Rates of Overall Survival and Intracranial Control in the Magnetic Resonance Imaging Era for Patients With Limited-Stage Small Cell Lung Cancer With and Without Prophylactic Cranial Irradiation Prophylactic Cranial Irradiation, Survival, and Risk of Brain Metastasis in Patients With Small Cell Lung, 2020-04-01

• Outcomes of re-irradiation for brain recurrence after prophylactic or therapeutic whole-brain irradiation for small cell lung Cancer: a retrospective analysis, 2018-12-29

• An Analysis of Factors Affecting Successful Clinical Trial Enrollment in the Context of Three Prospective Randomized Control Trials, 2016-11-27

• Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights, 2023-09-14

• Incidence of Second Malignancy after Successful Treatment of Limited-Stage Small-Cell Lung Cancer and Its Effects on Survival, 2017-08-10

• Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer, 2017-02-24

• Quantifying the Interfractional Displacement of the Gastroesophageal Junction during Radiation Therapy for Esophageal Cancer, 2012-03-21

• Screening and Validation of Molecular Targeted Radiosensitizers, 2021-07-31

• Smad4 Loss Correlates with Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation, 2018-01-18

• Dosimetric effects of jaw tracking in step-and-shoot intensity-modulated radiation therapy, 2012-03-08

• Cancer treatment-induced NAD+ depletion in premature senescence and late cardiovascular complications, 2022-04-29

• Exploring the synergy of radiative coupling and substrate undercut in arrayed gold nanodisks for economical, ultra-sensitive label-free biosensing, 2021-09-07

• An improved patient-derived xenograft humanized mouse model for evaluation of lung cancer immune responses, 2019-06-11

• The Impact of the Effective Dose to Immune Cells on Lymphopenia and Survival of Esophageal Cancer after Chemoradiotherapy, 2020-03-19

• Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma, 2015-03-09

• ATR-mediated CD47 and PD-L1 upregulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer, 2022-06-10

• Propensity score based comparison of long term outcomes with 3D conformal radiotherapy (3DCRT) versus Intensity Modulated Radiation Therapy (IMRT) in the treatment of esophageal cancer, 2012-08-03

• Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy, 2020-11-04

• Causes of Clonal Hematopoiesis: a Review, 2023-01-31

• Wee1 Kinase Inhibitor AZD1775 Effectively Sensitizes Esophageal Cancer to Radiotherapy, 2020-03-27

• Trends and Outcomes of Proton Radiation Therapy Use for Non-Small Cell Lung Cancer, 2018-11-30

• Stereotactic Ablative Radiotherapy for Operable Stage I Non-Small Cell Lung Cancer: Long-Term Results of the Single-Arm STARS Prospective Trial, 2021-09-13

• Evolving Practice Patterns in the Use of Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer Prophylactic Cranial Irradiation for Extensive-Stage Small Cell Lung Cancer, 2019-08-14

• Spatial Interaction of Tumor Cells and Regulatory T cells Correlates with Survival in Non-Small Cell Lung Cancer, 2018-02-04

• Prediction and diagnosis of interval metastasis after neoadjuvant chemoradiotherapy for oesophageal cancer using18F-FDG PET/CT, 2018-04-16

• Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy, 2019-03-18

• Prognostic Significance of Pretreatment Total Lymphocyte Count and Neutrophil-to-Lymphocyte Ratio in Extensive-Stage Small-Cell Lung Cancer, 2018-02-02

• Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma, 2019-07-23

• Association of Driver Oncogene Variations With Outcomes in Patients With Locally Advanced Non-Small Cell Lung Cancer Treated With Chemoradiation and Consolidative Durvalumab Driver Oncogene Variations and Patients With Locally Advanced NSCLC, 2022-06-06

• Independent Reproduction of the FLASH Effect on the Gastrointestinal Tract: A Multi-Institutional Comparative Study, 2023-04-02

• HSPB1Gene Polymorphisms Predict Risk of Mortality for U.S. Patients after Radio(chemo)therapy for Non-Small-Cell Lung Cancer, 2012-05-19

• The emerging field of radiomics in esophageal cancer: current evidence and future potential, 2018-12-21

• Proton Beam Therapy and concurrent chemotherapy for esophageal cancer, 2012-03-13

• Influence of Preoperative Radiation Field on Postoperative Leak Rates in Esophageal Cancer Patients after Trimodality Therapy, 2014-03-13

• Toxicity and Survival after Intensity-Modulated Proton Therapy (IMPT) versus Passive Scattering Proton Therapy (PSPT) for Non-Small Cell Lung Cancer, 2020-10-22

• Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer, 2023-02-08

• Assessment of Prognostic Value of High-Sensitivity Cardiac Troponin T for Early Prediction of Chemoradiotherapy-Induced Cardiotoxicity in Non-Small Cell Lung Cancer Patients: A Secondary Analysis of a Prospective Randomized Trial hs-TnT for CRT related cardiotoxicity in NSCLC, 2021-07-21

• Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling, 2019-09-25

• Integrating genomic features for noninvasive early lung cancer detection, 2020-03-25

• The abscopal effect in patients with cancer receiving immunotherapy, 2023-03-08

• A Prospective Exploratory Analysis of Cardiac Biomarkers and Electrocardiogram Abnormalities in Patients Receiving Thoracic Radiation Therapy with High-Dose Heart Exposure, 2014-06-22

• Adaptation and dosimetric commissioning of a synchrotron-based proton beamline for FLASH experiments, 2022-08-05

• The Impact of Radiation Dose to Heart Substructures on Major Coronary Events and Patient Survival after Chemoradiation Therapy for Esophageal Cancer, 2022-03-03

• Predictors of Postoperative Complications After Trimodality Therapy for Esophageal Cancer, 2013-08-01

• Prediction of severe lymphopenia during chemoradiotherapy for esophageal cancer: development and validation of a pretreatment nomogram, 2019-07-29

• Spatial mapping of the biologic effectiveness of scanned particle beams: towards biologically optimized particle therapy, 2015-05-18

• Radiation therapy induces immunosenescence mediated by p90RSK, 2022-11-07

• The value of18F-FDG PET before and after induction chemotherapy for the early prediction of a poor pathologic response to subsequent preoperative chemoradiotherapy in oesophageal adenocarcinoma, 2016-08-11

• Endothelial activation and fibrotic changes are impeded by laminar flow-induced CHK1-SENP2 activity through mechanisms distinct from endothelial-to-mesenchymal cell transition, 2023-08-30

• A novel deep learning model using dosimetric and clinical information for grade 4 radiotherapy-induced lymphopenia prediction, 2020-02-04

• Radiation Modality Utilization and Cardiopulmonary Mortality Risk in the Elderly with Esophageal Cancer, 2015-12-30

• Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer, 2021-10-20

• p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway, 2020-11-13

• Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition, 2014-12-08

• Association of clonal hematopoiesis mutations with clinical outcomes: A systematic review and meta-analysis, 2022-01-19

• Phase I Study of Dose Escalation in Hypofractionated Proton Beam Therapy for Thoracic Malignancies, 2013-05-18

• PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness, 2016-02-04

• Circulating tumor DNA analysis for detection of minimal residual disease after chemoradiotherapy for localized esophageal cancer, 2019-11-09

• Comparison of locoregional versus extended locoregional radiation volumes for patients with non-metastatic gastro-esophageal junction carcinomas, 2015-01-04

• Predictors for Locoregional Recurrence for Clinical Stage III-N2 Non-small Cell Lung Cancer with Nodal Downstaging After Induction Chemotherapy and Surgery, 2012-12-20

• Active Surveillance for Medically Inoperable Stage IA Lung Cancer in the Elderly, 2018-10-22

• Accelerated hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for the treatment of inoperable non-small cell lung cancer, 2012-03-15

• Therapy resistant cancer stem cells have differing sensitivity to photon versus proton beam radiation, 2013-10-17

• Outcome of Trimodality-Eligible Esophagogastric Cancer Patients Who Declined Surgery after Preoperative Chemoradiation, 2012-09-04

• Radiation-Induced Lymphopenia Risks of Photon Versus Proton Therapy for Esophageal Cancer Patients, 2021-04-07

• Obesity and Outcomes in Patients Treated with Chemoradiotherapy for Esophageal Carcinoma, 2013-04-26

• Health Care Resource Utilization for Esophageal Cancer Using Proton versus Photon Radiation Therapy, 2022-06-23

• Plasmonic nano-aperture label-free imaging (PANORAMA), 2020-11-16

• Prognostic Impact of Radiation Therapy to the Primary Tumor in Patients With Non-small Cell Lung Cancer and Oligometastasis at Diagnosis, 2012-04-13

• Combining Immunotherapy and Radiotherapy for Cancer Treatment: Current Challenges and Future Directions, 2018-03-05

• Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer, 2020-06-26

• Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells, 2019-09-25

• Preoperative prediction of pathologic response to neoadjuvant chemoradiotherapy in patients with esophageal cancer using18F-FDG PET/CT and DW-MRI: a prospective multicenter study, 2020-01-25

• Moving Beyond the Standard of Care: Accelerate Testing of Radiation-Drug Combinations, 2021-08-25

• Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome, 2019-11-20

• Bayesian regression analyses of radiation modality effects on pericardial and pleural effusion and survival in esophageal cancer, 2016-08-22

• ASO Author Reflections: Predicting Early Recurrence After Trimodality Therapy for Esophageal Adenocarcinoma, 2018-11-15

• A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries, 2019-12-17

• Preoperative Nomogram to Risk Stratify Patients for the Benefit of Trimodality Therapy in Esophageal Adenocarcinoma, 2018-03-22

• Circulating Tumor DNA Dynamics Predict Benefit from Consolidation Immunotherapy in Locally Advanced Non-Small Cell Lung Cancer, 2020-01-20

• Author Correction: Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome, 2020-06-30

• The overall survival impact of prophylactic cranial irradiation in limited-stage small-cell lung cancer: A systematic review and meta-analysis, 2022-02-17

• Prognosis of severe lymphopenia after postoperative radiotherapy in non-small cell lung cancer: Results of a long-term follow up study, 2021-03-12

• Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy, 2020-10-02

• Corrigendum: p90RSK-MAGI1 Module Controls Endothelial Permeability by Post-translational Modifications of MAGI1 and Hippo Pathway, 2021-02-19

• Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotype in lymphocytes, 2020-09-09