Dr. Steven Deeks, MD

• Internal Medicine

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• University Of California At San Francisco

  Medical School, 1990

• The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation, 2010-11-04

• Transmitted Drug Resistance in Persons with Acute/Early HIV-1 in San Francisco, 2002-2009, 2010-12-10

• CD56negCD16+NK cells are activated mature NK cells with impaired effector function during HIV-1 infection, 2013-12-18

• IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells, 2006-07-21

• Multiply spliced HIV RNA is a predictive measure of virus productionex vivoandin vivofollowing reversal of HIV latency, 2021-02-26

• Hematopoietic stem cell-based gene therapy for HIV disease, 2012-02-03

• Human Endogenous Retrovirus K106 (HERV-K106) Was Infectious after the Emergence of Anatomically Modern Humans, 2011-05-25

• Differential microRNA regulation ofHLA-Cexpression and its association with HIV control, 2011-04-17

• A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir, 2021-04-12

• Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase 2b Trial, 2018-10-09

• Antiretroviral therapy concentrations differ in gut versus lymph node tissues and are associated with HIV viral transcription by a novel RT-ddPCR assay, 2020-04-15

• Expression profile of host restriction factors in HIV-1 elite controllers, 2013-10-16

• Composition and Function of T Cell Subpopulations Are Slow to Change Despite Effective Antiretroviral Treatment of HIV Disease, 2014-01-21

• Short-term Disulfiram to Reverse Latent HIV Infection: A Phase 2 Dose Escalation Study, 2015-11-17

• Prospective Antiretroviral Treatment of Asymptomatic, HIV-1 Infected Controllers, 2013-10-10

• TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection, 2016-01-07

• Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease, 2012-02-16

• A Randomized Controlled Trial of Lisinopril to Decrease Lymphoid Fibrosis in Antiretroviral-Treated, HIV-infected Individuals, 2017-08-02

• Treatment-Mediated Alterations in HIV Fitness Preserve CD4+T Cell Counts but Have Minimal Effects on Viral Load, 2010-11-24

• Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral-Treated HIV Infection, 2009-04-15

• Cytomegalovirus-Specific T Cells Persist at Very High Levels during Long-Term Antiretroviral Treatment of HIV Disease, 2010-01-29

• HIV Infection, Inflammation, Immunosenescence, and Aging, 2013-08-13

• Programmed death-1 expression on CD4+and CD8+T cells in treated and untreated HIV disease, 2014-07-31

• A Low T Regulatory Cell Response May Contribute to Both Viral Control and Generalized Immune Activation in HIV Controllers, 2011-01-31

• A Randomized, Controlled Trial of Mindfulness-Based Stress Reduction in HIV Infection, 2018-05-26

• Role of Viral Replication, Antiretroviral Therapy, and Immunodeficiency in HIV- Associated Atherosclerosis, 2009-06-01

• A chronic kidney disease risk score to determine tenofovir safety in a prospective cohort of HIV-positive male veterans, 2014-06-01

• New insights into the heterogeneity of Th17 subsets contributing to HIV-1 persistence during antiretroviral therapy, 2016-08-24

• Association between statin use, atherosclerosis, and mortality in HIV-infected adults, 2020-04-30

• Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4, 2023-01-26

• HLA B*57 Does Not Fully Explain Hepatitis C Clearance in HIV Controllers, 2013-11-13

• High Transmissibility During Early HIV Infection Among Men Who Have Sex With Men-San Francisco, California, 2014-12-26

• Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to-Moderate Adherence Levels, 2008-07-30

• Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons, 2011-06-19

• Cerebrospinal fluid signs of neuronal damage after antiretroviral treatment interruption in HIV-1 infection, 2005-08-18

• Higher CD27+CD8+T Cells Percentages during Suppressive Antiretroviral Therapy Predict Greater Subsequent CD4+T Cell Recovery in Treated HIV Infection, 2013-12-31

• HIV-infected persons continue to lose kidney function despite successful antiretroviral therapy, 2009-10-23

• Anti-HIV Antibody Responses and the HIV Reservoir Size during Antiretroviral Therapy, 2016-08-02

• Virome analysis of antiretroviral-treated HIV patients shows no correlation between T-cell activation and anelloviruses levels, 2015-10-08

• Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence, 2023-10-02

• A closer look at hepatitis C clearance in HIV controllers: a response, 2014-05-15

• Association of Viral Persistence and Atherosclerosis in Adults With Treated HIV Infection Association of Viral Persistence and Atherosclerosis in Adults With Treated HIV Infection, 2020-10-29

• Assessing intra-lab precision and inter-lab repeatability of outgrowth assays of HIV-1 latent reservoir size, 2019-04-12

• Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults A Systematic Review and Meta-analysis Use of Cardiopulmonary Exercise Testing to Evaluate Long COVID-19 Symptoms in Adults, 2022-10-12

• Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naive to Antiretroviral Therapy: A Pilot Randomized Trial, 2016-01-21

• Geriatric Syndromes in Older HIV-Infected Adults, 2015-06-01

• Discordance between peripheral and colonic markers of inflammation during suppressive ART, 2014-02-01

• PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+T cells from ART-suppressed individuals, 2019-02-18

• CD4+and CD8+T Cell Activation Are Associated with HIV DNA in Resting CD4+T Cells, 2014-10-23

• The Association Between Kidney Function and Albuminuria with Cardiovascular Events in HIV-Infected Persons, 2010-01-25

• Regulatory B Cells Inhibit Cytotoxic T Lymphocyte (CTL) Activity and Elimination of Infected CD4 T Cells afterIn VitroReactivation of HIV Latent Reservoirs, 2014-04-16

• Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy, 2023-01-11

• p16INK4aExpression and Immunologic Aging in Chronic HIV Infection, 2016-11-18

• Perturbed CD8+T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals, 2017-01-13

• Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19, 2023-07-31

• Soluble immune checkpoints as correlates for HIV persistence and T cell function in people with HIV on antiretroviral therapy, 2023-03-28

• The Breadth of the Neutralizing Antibody Response to Original SARS-CoV-2 Infection is Linked to the Presence of Long COVID Symptoms, 2023-03-31

• SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency, 2017-05-10

• Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy, 2014-11-13

• Prolonged and Substantial Discordance in Prevalence of Raltegravir-Resistant HIV-1 in Plasma versus PBMC Samples Revealed by 454 "Deep” Sequencing, 2012-09-26

• Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue, 2018-06-01

• multiSero: open multiplex-ELISA platform for analyzing antibody responses to SARS-CoV-2 infection, 2021-05-11

• CD4 count at presentation for HIV care in the United States and Canada: Are those over 50 years more likely to have a delayed presentation?, 2010-12-15

• Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART, 2021-01-19

• HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream ofHLA-C, 2010-05-12

• Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses, 2020-01-29

• Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals, 2014-08-28

• A common allele of HLA mediates asymptomatic SARS-CoV-2 infection, 2022-10-12

• A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses, 2019-01-30

• Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus, 2023-01-30

• CD8+T cells in lymphoid tissues exhibit distinct functional and transcriptional signatures that associate with elite control of HIV, 2019-12-18

• Cortisol Patterns Are Associated with T Cell Activation in HIV, 2013-07-26

• Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells From HIV+ Controllers and ART-Suppressed Individuals, 2022-01-27

• Comparison of HIV DNA and RNA in Gut-Associated Lymphoid Tissue of HIV-Infected Controllers and Non-controllers, 2013-09-10

• Human Endogenous Retrovirus Expression Is Inversely Associated with Chronic Immune Activation in HIV-1 Infection, 2012-08-07

• Immune Activation, Cd4+ T Cell Counts, and Viremia Exhibit Oscillatory Patterns over Time in Patients with Highly Resistant HIV Infection, 2011-06-20

• Human Herpesvirus Replication and Abnormal CD8+ T Cell Activation and Low CD4+ T Cell Counts in Antiretroviral-Suppressed HIV-Infected Patients, 2009-04-17

• Host Response to Translocated Microbial Products Predicts Outcomes of Patients with HBV or HCV infection, 2011-07-02

• Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease, 2018-04-13

• Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy, 2016-05-12

• Human Immunodeficiency Virus (HIV)-Infected CCR6+Rectal CD4+T Cells and HIV Persistence On Antiretroviral Therapy, 2019-12-04

• Predominance of Weakly Cytotoxic, T-betLowEomesNegCD8+T-cells in Human Gastrointestinal Mucosa: Implications for HIV Infection, 2016-11-09

• Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment, 2005-11-02

• The Risk of Virologic Failure Decreases with Duration of HIV Suppression, at Greater than 50% Adherence to Antiretroviral Therapy, 2009-09-29

• Mitral Annular and Coronary Artery Calcification Are Associated with Mortality in HIV-Infected Individuals, 2015-07-01

• IL-1ß Inhibition Reduces Atherosclerotic Inflammation in HIV Infection, 2018-12-04

• Do Biomarkers Of Inflammation, Monocyte Activation And Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?, 2016-06-01

• HIV RNA level in early infection is predicted by viral load in the transmission source, 2010-04-24

• First-in-human immunoPET imaging of HIV-1 infection using89Zr-labeled VRC01 broadly neutralizing antibody, 2022-03-09

• HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality, 2014-05-15

• Increased CD34+/KDR+cells are not associated with carotid artery intima-media thickness progression in chronic HIV-positive subjects, 2011-12-16

• Everolimus, an mTORC1/2 inhibitor, in ART-suppressed individuals who received solid organ transplantation: A prospective study, 2020-09-15

• CCR5AS lncRNA variation differentially regulates CCR5, influencing HIV disease outcome, 2019-06-17

• Considerations for designing and implementing combination HIV cure trials: findings from a qualitative in-depth interview study in the United States, 2021-10-18

• Psoriasis risk SNPs and their association with HIV-1 control, 2016-10-31

• Differential Expression of CD8+ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection, 2018-01-19

• Plasma-Derived HIV-1 Virions Contain Considerable Levels of Defective Genomes, 2022-03-23

• Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection, 2020-04-30

• Influence of HAART on Alternative Reading Frame Immune Responses over the Course of HIV-1 Infection, 2012-06-29

• Ethical and practical considerations for cell and gene therapy toward an HIV cure: findings from a qualitative in-depth interview study in the United States, 2022-04-09

• HIV-1 Genomes Are Enriched in Memory CD4+T-Cells with Short Half-Lives, 2021-09-21

• Carotid Intima-Media Thickness Progression in HIV-Infected Adults Occurs Preferentially at the Carotid Bifurcation and Is Predicted by Inflammation, 2012-04-24

• Defective proviruses rapidly accumulate during acute HIV-1 infection, 2016-08-08

• Drug Effectiveness Explained: The Mathematics of Antiviral Agents for HIV, 2011-07-13

• Recommendations for Analytical Antiretroviral Treatment Interruptions in HIV Research Trials - Report of a Consensus Meeting, 2019-03-15

• Impact of HIV on CD8+ T Cell CD57 Expression Is Distinct from That of CMV and Aging, 2014-02-27

• Two-way Bayesian hierarchical phylogenetic models: An application to the co-evolution of gp120 and gp41 during and after enfuvirtide treatment, 2009-01-15

• Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+T Cells from Effectively Treated Participants, 2017-10-17

• Long term consequences of the delay between virologic failure of highly active antiretroviral therapy and regimen modification, 2008-10-18

• Detection of HIV-1-Specific Gastrointestinal Tissue Resident CD8+T-cells in Chronic Infection, 2017-11-15

• The Immunologic Effects of Mesalamine in Treated HIV-Infected Individuals with Incomplete CD4+ T Cell Recovery: A Randomized Crossover Trial, 2014-12-29

• Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infection, 2022-05-23

• Lack of Evidence for mtDNA as a Biomarker of Innate Immune Activation in HIV Infection, 2012-11-29

• Differential Expression of CD96 Surface Molecule Represents CD8+T Cells with Dissimilar Effector Function during HIV-1 Infection, 2012-12-13

• Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19, 2021-03-12

• Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community, 2020-08-17

• Why and where an HIV cure is needed and how it might be achieved, 2019-12-18

• Carotid Intima-Media Thickness Among HIV-Infected Patients Without Coronary Calcium, 2011-12-09

• Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+T cell subsetsin vivo, 2021-04-27

• Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites Lee et al., 2020-01-17