Dr. Spyros Kalams, MD

• Infectious Disease Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• University Of Connecticut

  Medical School, 1987

• Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations, 2015-12-31

• Adaptation to HLA-associated immune pressure over the course of HIV infection and in circulating HIV-1 strains, 2022-12-16

• Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response, 2023-03-29

• Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis, 2020-12-17

• Cross-Reactivity to Mutated Viral Immune Targets Can Influence CD8+T Cell Functionality: An Alternative Viral Adaptation Strategy, 2021-10-26

• Leptin Promotes Greater Ki67 Expression in CD4+T Cells From Obese Compared to Lean Persons Living With HIV, 2022-01-17

• Emerging studies of human HIV-specific antibody repertoires, 2010-05-26

• Adipose Tissue in Persons With HIV Is Enriched for CD4+T Effector Memory and T Effector Memory RA+Cells, Which Show Higher CD69 Expression and CD57, CX3CR1, GPR56 Co-expression With Increasing Glucose Intolerance, 2019-03-19

• Reducing the Activity and Secretion of Microbial Antioxidants Enhances the Immunogenicity of BCG, 2009-05-13

• CMV epitope-specific CD4+T cells are inflated in HIV+CMV+subjects, 2017-10-02

• Human Antibodies that Recognize Novel Immunodominant Quaternary Epitopes on the HIV-1 Env Protein, 2016-07-13

• Greater activation of peripheral T follicular helper cells following high dose influenza vaccine in older adults forecasts seroconversion, 2016-12-03

• Anti-Cytomegalovirus CD4+T Cells are Associated with Subclinical Atherosclerosis in Persons with HIV, 2021-02-11

• Safety and Immunogenicity of an HIV-1GagDNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults, 2012-01-05

• Postpartum Viral Load Rebound in HIV-1-Infected Women Treated with Highly Active Antiretroviral Therapy: AIDS Clinical Trials Group Protocol A5150, 2011-11-11

• Adipose Tissue is Enriched for Activated and Late-differentiated CD8+ T cells, and Shows Distinct CD8+ Receptor Usage, Compared to Blood in HIV-infected Persons, 2018-02-01

• Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV, 2023-08-30

• Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein, 2015-07-30

• CD4+T cells expressing CX3CR1, GPR56, with variable CD57 are associated with cardiometabolic diseases in persons with HIV, 2023-02-14

• Neither vaginal nor buccal administration of 800 µg misoprostol alters mucosal and systemic immune activation or the cervicovaginal microbiome: a pilot study, 2016-09-16

• Circulating Markers of Immunologic Activity Reflect Adiposity in Persons with HIV on Antiretroviral Therapy, 2018-09-01

• Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP®DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults, 2020-12-07

• Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV, 2019-12-10

• Dominant clonotypes within HIV-specific T cell responses are PD-1hiand CD127lowand display reduced variant cross-reactivity1, 2011-05-11

• The soluble epoxide hydrolase inhibitor GSK2256294 decreases the proportion of adipose pro-inflammatory T cells, 2021-12-15

• Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth, 2018-12-19

• Identification of a CCR5-Expressing T Cell Subset That Is Resistant to R5-Tropic HIV Infection, 2007-04-27