Dr. Robert Gatenby, MD

• Diagnostic Radiology

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• Jeanes Hospital|penn State University Hershey Medical Center

  Residency Hospital, 1989

• Evolutionary strategy for systemic therapy of metastatic breast cancer: balancing response with suppression of resistance, 2014-11-06

• Coordination games in cancer, 2022-01-21

• First strike - second strike strategies in metastatic cancer: Lessons from the evolutionary dynamics of extinction, 2019-06-20

• QIN "Radiomics: The Process and the Challenges”, 2012-08-13

• Variance of Standardized Uptake Values for FDG-PET/CT Greater in Clinical Practice than Under Ideal Study Settings, 2012-12-11

• Back to basic: Trials and tribulations of alkalizing agents in cancer, 2022-11-14

• Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma, 2015-03-04

• Adaptation to stochastic temporal variations in intratumoral blood flow: the Warburg effect as a bet-hedging strategy, 2017-05-15

• Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer, 2016-02-24

• Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer, 2016-11-01

• Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies, 2018-01-30

• Leaky Vessels as a Potential Source of Stromal Acidification in Tumours, 2010-08-10

• Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments, 2019-10-22

• A Mathematical Model of Tumour and Blood pHe Regulation: TheBuffering System, 2010-12-15

• ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: a Multi-disciplinary Team-based, Multifactorial Analytical Approach, 2020-07-02

• Predator-Prey in Tumor-Immune Interactions: A Wrong Model or Just an Incomplete One?, 2021-08-31

• GLUT1 production in cancer cells: a tragedy of the commons, 2022-06-29

• Order in a multidimensional system, 2011-07-19

• Evolutionary approaches to prolong progression-free survival in breast cancer, 2012-10-12

• Response to Mistry, 2021-01-12

• Principle of Maximum Fisher Information from Hardy's Axioms Applied to Statistical Systems, 2013-10-28

• Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity, 2010-04-20

• Evolutionary advantage of directional symmetry breaking in self-replicating polymers, 2018-03-12

• Proton dynamics in cancer, 2010-06-15

• Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy, 2022-05-10

• Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane, 2014-06-05

• AI-Radiomics Can Improve Inclusion Criteria and Clinical Trial Performance, 2022-02-02

• Pathology to Enhance Precision Medicine in Oncology: Lessons From Landscape Ecology, 2015-10-02

• Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases, 2009-03-10

• Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane, 2015-12-10

• The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right, 2019-08-06

• Tris -base buffer: a promising new inhibitor for cancer progression and metastasis, 2017-05-29

• Adaptive Therapy, 2009-06-01

• Adaptation to Survival in Germinal Center is the Initial Step in Onset of Indolent Stage of Multiple Myeloma, 2011-10-12

• Darwinian dynamics of intratumoral heterogeneity: not solely random mutations but also variable environmental selection forces, 2016-03-23

• Integrating genetic and nongenetic drivers of somatic evolution during carcinogenesis: The biplane model, 2020-05-13

• Cellular information dynamics through transmembrane flow of ions, 2017-11-08

• Of cancer and cavefish, 2013-07-29

• Prediction of drug response in breast cancer using integrative experimental/computational modeling, 2009-04-14

• Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer, 2017-11-28

• Heterogeneity in Intratumoral Regions With Rapid Gadolinium Washout Correlates With Estrogen Receptor Status and Nodal Metastasis, 2015-04-17

• Evolution of Tumor Invasiveness: The Adaptive Tumor Microenvironment Landscape Model, 2011-08-22

• Tumor Evolution in Space: The Effects of Competition Colonization Tradeoffs on Tumor Invasion Dynamics, 2013-03-06

• Stem Cell Plasticity and Niche Dynamics in Cancer Progression, 2016-09-08

• Tumour-Stromal Interactions in Acid-Mediated Invasion: A Mathematical Model, 2010-09-08

• Evolutionary advantage of anti-parallel strand orientation of duplex DNA, 2020-06-18

• A Phase 1b Adaptive Androgen Deprivation Therapy Trial in Metastatic Castration Sensitive Prostate Cancer, 2022-10-25

• Cancer treatment as a game: integrating evolutionary game theory into the optimal control of chemotherapy, 2012-11-29

• Riparian ecosystems in human cancers, 2012-10-10

• A multiscale model of the bone marrow and hematopoiesis, 2013-07-05

• Eradicating Metastatic Cancer and the Eco-Evolutionary Dynamics of Anthropocene Extinctions, 2019-11-26

• Evolutionary dynamics in cancer therapy, 2011-08-23

• The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand, 2017-09-18

• Vascular measurements correlate with estrogen receptor status, 2014-04-23

• A theoretical quantitative model for evolution of cancer chemotherapy resistance, 2010-04-20

• Information Dynamics in Living Systems: Prokaryotes, Eukaryotes, and Cancer, 2011-07-19

• Evolutionary perspective of cancer: myth, metaphors, and reality, 2015-05-27

• Growth of stable order in eukaryotes from environmental energy, 2013-02-28

• Is ThereOneKey Step in the Metastatic Cascade?, 2021-07-22

• Frequency-dependent interactions determine outcome of competition between two breast cancer cell lines, 2021-03-01

• Multiscale Modelling of Vascular Tumour Growth in 3D: The Roles of Domain Size and Boundary Conditions, 2011-04-13

• Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302, 2015-01-29

• Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy, 2019-04-16

• Exploiting evolution to treat drug resistance: Combination therapy and the double bind, 2012-03-19

• Automated Delineation of Lung Tumors from CT Images Using a Single Click Ensemble Segmentation Approach, 2013-03-01

• Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model, 2023-10-10

• Cancer: an emergent property of disturbed resource-rich environments? Ecology meets personalized medicine, 2015-03-26

• Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model, 2011-11-19

• The evolutionary dynamics of cancer prevention, 2013-07-29

• Turnover modulates the need for a cost of resistance in adaptive therapy, 2020-11-10

• Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer, 2017-03-21

• Novel evolutionary dynamics of small populations in breast cancer adjuvant and neoadjuvant therapy, 2021-03-11

• Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance, 2015-09-11

• Defining cancer subpopulations by adaptive strategies rather than molecular properties provides novel insights into intratumoral evolution, 2017-03-01

• Buffer Therapy for Cancer, 2012-08-15

• Life history tradeoffs in cancer evolution, 2013-11-11

• Predicting malignant nodules from screening CTs, 2016-07-13

• Intermittent Hypoxia Selects for Genotypes and Phenotypes That Increase Survival, Invasion, and Therapy Resistance, 2015-03-26

• Coulomb Interactions between Cytoplasmic Electric Fields and Phosphorylated Messenger Proteins Optimize Information Flow in Cells, 2010-08-11

• Mistic: An open-source multiplexed image t-SNE viewer, 2022-06-02

• Cell Development obeys Maximum Fisher Information, 2013-06-01

• Transmissible cancers, are they more common than thought?, 2016-05-17

• The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion, 2009-03-10

• Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race, 2020-10-07

• Towards multi-drug adaptive therapy, 2020-01-16

• Evolutionary Analysis of TCGA Data Using Over- and Under- Mutated Genes Identify Key Molecular Pathways and Cellular Functions in Lung Cancer Subtypes, 2022-12-20

• The Physics of Cancer, 2019-04-24

• Prostate-specific antigen dynamics predict individual responses to intermittent androgen deprivation, 2020-04-09

• Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow, 2019-03-22

• Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox, 2012-09-03

• Macrophage-derived cholesterol contributes to therapeutic resistance in prostate cancer, 2021-07-23

• Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies, 2019-04-02