Dr. Jose Florez, MD

• Endocrinology, Diabetes & Metabolism

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Northwestern University

  Medical School, 1997

• English

• Spanish

• Metabolite Profiles and the Risk of Developing Diabetes, 2011-03-20

• The Type 2 Diabetes Knowledge Portal: an open access genetic resource dedicated to type 2 diabetes and related traits, 2023-03-23

• On the Verge of Precision Medicine in Diabetes, 2022-09-19

• Therapeutic challenges in diabetes prevention: We have not found the "exercise pill”, 2015-06-25

• Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium, 2022-03-11

• Ordered Stratification to Reduce Heterogeneity in Linkage to Diabetes-Related Quantitative Traits, 2008-07-24

• An expanded genome-wide association study of type 2 diabetes in Europeans, 2017-05-31

• Biogeographic Ancestry Is Associated with Higher Total Body Adiposity among African-American Females: The Boston Area Community Health Survey, 2015-04-13

• Genetic inactivation ofANGPTL4improves glucose homeostasis and is associated with reduced risk of diabetes, 2018-06-13

• Mendelian randomization study of obesity and cerebrovascular disease, 2020-02-19

• A Genome-Wide Association Study Reveals Variants inARL15that Influence Adiponectin Levels, 2009-12-11

• GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification, 2023-09-07

• Physical Activity Attenuates the Influence ofFTOVariants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children, 2011-11-01

• Precision medicine in diabetes: an opportunity for clinical translation, 2019-07-03

• Clear detection ofADIPOQlocus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals, 2009-12-02

• Replication of the association ofBDNFandMC4Rvariants with dietary intake in the Diabetes Prevention Program, 2016-06-25

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk, 2010-01-17

• Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis, 2021-03-04

• Genetic Counseling as a Tool for Type 2 Diabetes Prevention: A Genetic Counseling Framework for Common Polygenetic Disorders, 2013-07-29

• Effects of Genetic Variants Previously Associated with Fasting Glucose and Insulin in the Diabetes Prevention Program, 2012-09-11

• Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation, 2022-05-12

• Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose, 2018-04-06

• The genetics of type 2 diabetes: what have we learned from GWAS?, 2010-11-06

• Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program, 2022-07-28

• Variation at the Melanocortin 4 Receptor gene and response to weight-loss interventions in the Diabetes Prevention Program, 2013-06-25

• Branched chain and aromatic amino acids change acutely following two medical therapies for type 2 diabetes mellitus, 2013-08-15

• The Trans-Ancestral Genomic Architecture of Glycemic Traits, 2021-05-31

• Meta-analysis of Gene-Environment interaction: joint estimation of SNP and SNP×Environment regression coefficients, 2012-02-03

• A combined polygenic score of 21,293 rare and 22 common variants improves diabetes diagnosis based on hemoglobin A1C levels, 2022-10-24

• An update on the pharmacogenomics of metformin: progress, problems and potential, 2014-06-27

• Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes, 2012-08-12

• Polygenic scores, diet quality, and type 2 diabetes risk: An observational study among 35,759 adults from 3 US cohorts, 2022-04-26

• Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers, 2022-07-09

• An exome array study of the plasma metabolome, 2016-07-25

• Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes, 2021-06-09

• Interaction of diabetes genetic risk and successful lifestyle modification in the Diabetes Prevention Program, 2021-01-29

• Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease, 2022-06-28

• Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems, 2012-12-06

• Design of a Randomized Trial of Diabetes Genetic Risk Testing to Motivate Behavior Change: The Genetic Counseling/Lifestyle Change (GC/LC) Study to Prevent Diabetes, 2013-07-24

• The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities, 2017-12-11

• Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes, 2016-01-28

• Sequence data and association statistics from 12,940 type 2 diabetes cases and controls, 2017-12-19

• Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity, 2017-12-22

• Extending precision medicine tools to populations at high risk of type 2 diabetes, 2022-05-19

• Variation in the glucose transporter geneSLC2A2is associated with glycemic response to metformin, 2016-08-08

• A roadmap to achieve pharmacological precision medicine in diabetes, 2022-06-24

• The impact of non-additive genetic associations on age-related complex diseases, 2021-04-23

• Leveraging Genetics to Advance Type 2 Diabetes Prevention, 2016-07-26

• Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals, 2012-03-29

• Quantitative trait loci, G×E and G×G for glycemic traits: response to metformin and placebo in the Diabetes Prevention Program (DPP), 2022-03-09

• Variants in theCNR1and theFAAHgenes and adiposity traits in the community, 2009-01-22

• Loci for insulin processing and secretion provide insight into type 2 diabetes risk, 2023-01-23

• Assessing the phenotypic effects in the general population of rare variants in genes for a dominant mendelian form of diabetes, 2013-10-06

• Genome-wide association with diabetes-related traits in the Framingham Heart Study, 2007-09-19

• PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION, 2019-02-18

• Translocon declogger Ste24 protects against IAPP oligomer-induced proteotoxicity, 2018-03-08

• A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance, 2012-05-13

• Genome-wide Association Study of Change in Fasting Glucose over time in 13,807 non-diabetic European Ancestry Individuals, 2019-07-01

• Genome-wide association study and functional characterisation identifies candidate genes for insulin-stimulated glucose uptake, 2023-06-08

• Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease, 2022-12-22

• Association of Levels of Fasting Glucose and Insulin with Rare Variants at the Chromosome 11p11.2-MADDLocus: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study, 2014-05-07

• Genetics of diabetes and diabetes complications, 2020-05-12

• Genetic evidence that carbohydrate-stimulated insulin secretion leads to obesity, 2018-04-28

• Identification and Functional Characterization ofG6PC2Coding Variants Influencing Glycemic Traits Define an Effector Transcript at theG6PC2-ABCB11Locus, 2015-01-27

• Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, 2021-02-08

• Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine, 2019-07-19

• Effects of Initial Combinations of Gemigliptin Plus Metformin Compared with Glimepiride Plus Metformin on Gut Microbiota and Glucose Regulation in Obese Patients with Type 2 Diabetes: The INTESTINE Study, 2023-01-03

• The role of HSP70 on ENPP1 expression and insulin-receptor activation, 2008-12-16

• Association of African genetic ancestry with fasting glucose and HbA1clevels in non-diabetic individuals: the Boston Area Community Health (BACH) Prediabetes Study, 2014-06-19

• Common genetic determinants of vitamin D insufficiency: a genome-wide association study, 2010-06-10

• Common variants in and nearIRS1and subclinical cardiovascular disease in the Framingham Heart Study, 2013-04-22

• Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility, 2015-01-29

• Rare and low-frequency coding variants alter human adult height, 2017-02-01

• Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits, 2021-08-23

• Association of a 62 Variant Type 2 Diabetes Genetic Risk Score with Markers of Subclinical Atherosclerosis: A Transethnic, Multicenter Study, 2015-03-24

• Prospective functional classification of all possible missense variants inPPARG, 2016-10-17

• Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes, 2018-04-09

• Precision medicine in diabetes: a consensus report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), 2021-05-28

• The pharmacogenetics of metformin, 2017-08-03

• Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability, 2021-01-05

• Race-ethnic differences in the association of genetic loci with HbA1clevels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III), 2012-04-27

• Analysis of protein-coding genetic variation in 60,706 humans, 2016-08-18

• Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes Prevention Program, 2014-02-20

• Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+Recycling, 2019-01-24

• Common variation atPPARGC1A/Band change in body composition and metabolic traits following preventive interventions: the Diabetes Prevention Program, 2013-12-07

• Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program, 2012-08-30

• Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms, 2017-06-29

• The genetic architecture of type 2 diabetes, 2016-08-04

• Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes, 2018-05-30

• Precision subclassification of type 2 diabetes: a systematic review, 2023-10-05

• Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes, 2018-01-22

• Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis, 2018-09-21

• Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci, 2015-11-09

• Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium, 2018-07-09

• Algorithmic identification of atypical diabetes in electronic health record (EHR) systems, 2022-12-12

• Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls, 2019-05-22

• The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect, 2021-03-04

• Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis, 2017-09-12

• Variants in the melatonin receptor 1B gene (MTNR1B) influence fasting glucose levels, 2008-12-07

• New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes, 2012-09-20

• A low-frequency inactivatingAKT2variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk, 2017-03-24

• The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes, 2015-03-26

• Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19, 2022-07-21

• Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose, 2020-05-07

• The Cancer Associated FGFR4-G388R Polymorphism Enhances Pancreatic Insulin Secretion and Modifies the Risk of Diabetes, 2013-06-04

• Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps, 2018-10-08

• Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes and coronary heart disease, 2011-06-02

• MELATONIN EFFECTS ON GLUCOSE METABOLISM: TIME TO UNLOCK THE CONTROVERSY, 2020-01-01

• TCF7L2Polymorphism, Weight Loss and Proinsulin:Insulin Ratio in the Diabetes Prevention Program, 2011-07-26

• The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes, 2023-05-06

• Comprehensive genomic analysis of dietary habits in UK Biobank identifies hundreds of genetic associations, 2020-03-19

• Genetic variation inGIPRinfluences the glucose and insulin responses to an oral glucose challenge, 2010-01-17

• Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis, 2011-04-12

• Catechol-O-methyltransferase association with hemoglobin A1c, 2016-04-14