Dr. Jordan Smoller, MD

• Psychiatry

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• Harvard Medical School

  Medical School, 1992

• Placebo analgesia and reward processing: Integrating genetics, personality, and intrinsic brain activity, 2014-02-27

• Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: A preliminary study, 2008-12-05

• Neurophysiologic Effect of GWAS Derived Schizophrenia and Bipolar Risk Variants, 2013-11-08

• An independently validated, portable algorithm for the rapid identification of COPD patients using electronic health records, 2021-10-07

• Genome-wide association study implicates a novel RNA gene, the lincRNAAC068718.1, as a risk factor for post-traumatic stress disorder in women, 2013-09-08

• Increase in Suicidal Thinking During COVID-19, 2021-05-01

• Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder, 2018-05-31

• Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms, 2018-05-16

• Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4, 2011-09-18

• Greater male than female variability in regional brain structure across the lifespan, 2020-10-12

• Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group, 2021-10-01

• Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects, 2016-11-21

• Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies, 2016-02-01

• Pleiotropy in complex traits: challenges and strategies, 2013-06-11

• Pathway Analyses Implicate Glial Cells in Schizophrenia, 2014-02-24

• Psychiatric Genomics: An Update and an Agenda, 2017-10-03

• Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia, 2013-11-26

• Genome-Wide Association Study (GWAS) of Generalized Anxiety Symptoms in the Hispanic Community Health Study/Study of Latinos, 2016-05-09

• When is Pharmacogenetic Testing for Antidepressant Response Ready for the Clinic? A Cost-effectiveness Analysis Based on Data from the STAR*D Study, 2009-06-03

• Linkage Disequilibrium Mapping of the Chromosome 6q21-22.31 Bipolar I Disorder Susceptibility Locus, 2010-01-05

• Bipolar polygenic loading and bipolar spectrum features in major depressive disorder, 2014-04-12

• The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) Consortium: A Collaborative Cognitive and Neuroimaging Genetics Project, 2017-10-03

• Suggestive linkage of the CBCL juvenile bipolar disorder phenotype to 1p21, 6p21 and 8q21, 2010-02-11

• Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder, 2011-02-08

• Genomics and Psychological Resilience: A Research Agenda, 2019-07-24

• An Analysis of Two Genome-Wide Association Meta-Analyses Identifies a New Locus for Broad Depression Phenotype, 2016-12-08

• Joint contributions of rare CNVs and common SNPs to risk for schizophrenia, 2018-11-05

• Antidepressant Use, Depressive Symptoms, and Incident Frailty in Women Aged 65 and Older from the Women's Health Initiative Observational Study, 2012-05-09

• Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history, 2014-02-26

• Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria, 2020-09-02

• Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder, 2010-11-29

• The human cortex possesses a reconfigurable dynamic network architecture that is disrupted in psychosis, 2018-03-20

• Using Administrative Data to Predict Suicide After Psychiatric Hospitalization in the Veterans Health Administration System, 2020-05-06

• Developmental timing of child maltreatment and symptoms of depression and suicidal ideation in young adulthood: Results from the National Longitudinal Study on Adolescent Health, 2013-04-16

• A Quarter Century of Progress in Psychiatric Genetics, 2019-03-15

• Adverse obstetric outcomes during delivery hospitalizations complicated by suicidal behavior among US pregnant women, 2018-02-15

• Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder, 2019-05-01

• Aberrant glycosylation in schizophrenia: A review of 25 years of post-mortem brain studies, 2020-05-13

• Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development, 2023-05-18

• Childhood Adversity Is Associated with Adult Theory of Mind and Social Affiliation, but Not Face Processing, 2015-06-12

• Persistent Dissociation and its Neural Correlates Uniquely Predict Worse Outcomes after Trauma Exposure, 2022-06-22

• Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis, 2023-02-20

• Mapping genomic loci implicates genes and synaptic biology in schizophrenia, 2022-04-08

• Individual aesthetic preferences for faces are shaped mostly by environments, not genes, 2015-10-01

• What can we learn about polytrauma typologies by comparing population-representative to trauma-exposed samples: A Nepali example, 2022-07-08

• Minimal phenotyping yields genome-wide association signals of low specificity for major depression, 2020-03-30

• Prenatal antidepressant exposure is associated with risk for attention deficit-hyperactivity disorder but not autism spectrum disorder in a large health system, 2014-08-26

• Genome-wide polygenic score to predict chronic kidney disease across ancestries, 2022-06-16

• Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders, 2020-10-10

• Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women's Health Initiative Memory Study, 2012-02-03

• Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders, 2020-05-12

• Psychiatric Genetics and the Structure of Psychopathology, 2018-01-09

• Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits, 2021-06-15

• Characterizing the phenotypic and genetic structure of psychopathology in UK Biobank, 2023-09-06

• Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression, 2014-05-16

• Polygenic Risk for Major Depression is Associated with Lifetime Suicide Attempt in US Soldiers Independent of Personal and Parental History of Major Depression, 2021-07-21

• Ethical Considerations Related to Return of Results from Genomic Medicine Projects: The eMERGE Network (Phase III) Experience, 2018-01-03

• Contributions of the social environment to first-onset and recurrent mania, 2014-04-22

• Resilience to mental disorders in a low-income, non-Westernized setting, 2020-06-01

• Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes, 2023-09-18

• Genome-wide Analysis of Insomnia Disorder, 2018-03-08

• Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women, 2011-07-20

• Genetic overlap between vascular pathologies and Alzheimer's dementia and potential causal mechanisms, 2018-09-19

• Interrogating the genetic determinants of Tourette syndrome and other tic disorders through genome-wide association studies, 2019-03-01

• Characterisation of age and polarity at onset in bipolar disorder, 2021-12-01

• Genetic Risk Variants for Social Anxiety, 2017-01-06

• The interplay of childhood behavior problems and IQ in the development of later schizophrenia and affective psychoses, 2017-01-03

• A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts, 2021-05-04

• Benzodiazepine Use and Risk of Recurrence in Bipolar Disorder: A STEP-BD Report, 2023-02-21

• Common genetic variants influence human subcortical brain structures, 2015-01-21

• Use of serial smartphone-based assessments to characterize diverse neuropsychiatric symptom trajectories in a large trauma survivor cohort, 2023-01-07

• International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci, 2019-10-08

• Use of natural language processing in electronic medical records to identify pregnant women with suicidal behavior: towards a solution to the complex classification problem, 2018-12-10

• Rare coding variants in 10 genes confer substantial risk for schizophrenia, 2022-04-08

• Meta-Analysis of Genome-Wide Association Data of Bipolar Disorder and Major Depressive Disorder, 2010-03-30

• Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach, 2022-05-19

• Validation of Electronic Health Record Phenotyping of Bipolar Disorder and Controls, 2014-12-12

• S1 is associated with chronic low back pain: a functional and structural MRI study, 2013-08-21

• Prediction of Suicide Attempts Using Clinician Assessment, Patient Self-report, and Electronic Health Records Prediction of Suicide Attempt Using Clinician Assessment, Patient Self-report, and EHRs, 2022-01-27

• How Should We Reconcile Statistical and Clinician Predictions of Suicide Risk, 2021-03-11

• Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length, 2018-09-07

• Corticotrophin-releasing hormone type 1 receptor gene (CRHR1) variants predict posttraumatic stress disorder onset and course in pediatric injury patients, 2013-07-01

• Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers, 2019-04-15

• Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology, 2021-05-17

• The schizophrenia risk locus inSLC39A8alters brain metal transport and plasma glycosylation, 2020-08-04

• Novel genetic loci associated with hippocampal volume, 2017-01-18

• Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia, 2016-10-11

• Predicting at-risk opioid use three months after ed visit for trauma: Results from the AURORA study, 2022-09-23

• The Association between genetically determined ABO Blood Types and Major Depressive Disorder, 2021-02-24

• The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data, 2014-01-08

• Dissociable Genetic Contributions to Error Processing: A Multimodal Neuroimaging Study, 2014-07-10

• Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression, 2018-04-26

• Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues, 2022-01-12

• Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II, 2009-05-29

• Psychosocial stressors and the prognosis of major depression: a test of Axis IV, 2012-05-28

• N-glycome analysis detects dysglycosylation missed by conventional methods in SLC39A8 deficiency, 2020-09-14

• Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease, 2020-06-09

• Genetic validation of bipolar disorder identified by automated phenotyping using electronic health records, 2018-04-18

• Identification of common variants associated with human hippocampal and intracranial volumes, 2012-04-15

• Emotion sensitivity and self-reported symptoms of generalized anxiety disorder across the lifespan: A population-based sample approach, 2019-04-16

• Genetic Predictors of Risk and Resilience in Psychiatric Disorders: A Cross-Disorder Genome-wide Association Study of Functional Impairment in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia, 2013-09-13

• Functional connectivity of frontoparietal network predicts cognitive modulation of pain, 2012-12-20

• Multidimensional heritability analysis of neuroanatomical shape, 2016-11-15

• The Genetics of Bipolar Disorder, 2009-04-07

• The Evolution of a Large Biobank at Mass General Brigham, 2022-08-17

• Detecting potential pleiotropy across cardiovascular and neurological diseases using univariate, bivariate, and multivariate methods on 43,870 individuals from the eMERGE network, 2018-12-13

• The AURORA Study: A Longitudinal, Multimodal Library of Brain Biology and Function after Traumatic Stress Exposure, 2019-11-19

• Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression, 2020-03-01

• Cross-Disorder Genomewide Analysis of Schizophrenia, Bipolar Disorder, and Depression, 2010-08-16

• Predictive structured-unstructured interactions in EHR models: A case study of suicide prediction, 2022-01-27

• GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology, 2018-12-21

• Sex-Dependent Shared and Non-Shared Genetic Architecture Across Mood and Psychotic Disorders, 2021-03-23

• Genome-Wide Association Study (GWAS) and Genome-Wide Environment Interaction Study (GWEIS) of Depressive Symptoms in African American and Hispanic/Latina Women, 2016-02-24

• Plasma metabolomic profiles associated with chronic distress in women, 2021-09-20

• Large-scale real-world data analysis identifies comorbidity patterns in schizophrenia, 2022-04-11

• Improving risk prediction for target subpopulations: Predicting suicidal behaviors among multiple sclerosis patients, 2023-02-16

• Maternal vitamin D status during pregnancy and offspring risk of childhood/adolescent depression: Results from the Avon Longitudinal Study of Parents and Children (ALSPAC), 2020-01-07

• Genomewide Analyses of Psychological Resilience in US Army Soldiers, 2019-05-13

• Genetic and Clinical Predictors of Sexual Dysfunction in Citalopram-Treated Depressed Patients, 2009-03-18

• Biological Insights From 108 Schizophrenia-Associated Genetic Loci, 2014-07-22

• Physical activity offsets genetic risk for incident depression assessed via electronic health records in a biobank cohort study, 2019-11-05

• Patterns of deficits in brain function in bipolar disorder and schizophrenia: a cluster analytic study, 2012-08-24

• Contribution of rare copy number variants to bipolar disorder risk is limited to schizoaffective cases, 2018-12-20

• Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene,SNRNP35, Specific to Military Cohorts, 2020-06-02

• Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study, 2016-01-22

• An exposure-wide and Mendelian randomization approach to identifying modifiable factors for the prevention of depression, 2020-08-14

• A Hypomethylating Variant ofMTHFR, 677C>T, Blunts the Neural Response to Errors in Patients with Schizophrenia and Healthy Individuals, 2011-09-28

• Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association, 2013-07-31

• Mega-analysis methods in ENIGMA : The experience of the generalized anxiety disorder working group, 2020-06-29

• Characterizing mood disorders in the AFFECT study: a large, longitudinal, and phenotypically rich genetic cohort in the US, 2022-03-25

• Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic, and molecular genetic levels of analysis, 2022-05-05

• The evaluation of tools used to predict the impact of missense variants is hindered by two types of circularity, 2015-03-26

• Genomic influences on self-reported childhood maltreatment, 2020-01-27

• The schizophrenia-associated variant inSLC39A8alters protein glycosylation in the mouse brain, 2022-03-08

• Novel genetic loci underlying human intracranial volume identified through genome-wide association, 2016-10-03

• Does developmental timing of exposure to child maltreatment predict memory performance in adulthood? Results from a large, population-based sample, 2015-11-14

• Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry Generalizability of Polygenic Risk Scores for Breast Cancer by Race/Ethnicity, 2021-08-04

• Feasibility of studying brain morphology in major depressive disorder with structural magnetic resonance imaging and clinical data from the electronic medical record: A pilot study, 2012-11-11

• Recurrent, Robust and Scalable Patterns Underlie Human Approach and Avoidance, 2010-05-26

• RELATIONSHIP BETWEEN GENETIC VARIATION IN THE GLUTAMINASE GENEGLS1AND BRAIN GLUTAMINE/GLUTAMATE RATIO MEASUREDIN VIVO, 2011-03-31

• Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia, 2012-06-12

• An Electronic Health Records Study of Long-term Weight Gain Following Antidepressant Use, 2023-02-22

• Dissecting the heterogeneity of posttraumatic stress disorder: differences in polygenic risk, stress exposures, and course of PTSD subtypes, 2022-11-01

• Exome sequencing in bipolar disorder identifiesAKAP11as a risk gene shared with schizophrenia, 2022-04-11

• Genome-wide Association Study of Shared Liability to Anxiety Disorders in Army STARRS, 2019-12-30

• Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder, 2015-02-26

• Attention bias to emotional faces varies by IQ and anxiety in Williams syndrome, 2016-02-23

• Socio-demographic and trauma-related predictors of PTSD within eight weeks of a motor vehicle collision in the AURORA study, 2020-10-19

• Antidepressant Use and Risk of Incident Cardiovascular Morbidity and Mortality Among Postmenopausal Women in the Women's Health Initiative Study, 2009-12-14

• A Kernel Machine Method for Detecting Effects of Interaction Between Multidimensional Variable Sets: An Imaging Genetics Application, 2015-01-16

• Relations of Depressive Symptoms and Antidepressant Use to Body Mass Index and Selected Biomarkers for Diabetes and Cardiovascular Disease, 2013-06-13

• Individual Differences in Amygdala-Medial Prefrontal Anatomy Link Negative Affect, Impaired Social Functioning, and Polygenic Depression Risk, 2012-12-12

• A Randomized Multi-Center Investigation of Folate Plus B12 Supplementation in Schizophrenia, 2015-03-24

• Multivariate genomewide linkage scan of neurocognitive traits and ADHD symptoms: Suggestive linkage to 3q13, 2008-12-05

• Hypertension prevalence in theAll of UsResearch Program among groups traditionally underrepresented in medical research, 2021-06-22

• Polygenic Risk for Depression Increases Risk of Ischemic Stroke: from the Stroke Genetics Network (SiGN) Study, 2018-02-08

• AI-assisted prediction of differential response to antidepressant classes using electronic health records, 2023-04-26

• Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years, 2021-02-17

• Use of the PsycheMERGE Network to Investigate the Association Between Depression Polygenic Scores and White Blood Cell Count Use of the PsycheMERGE Network to Investigate Depression Scores and White Blood Cell Count, 2021-10-20

• Frontal P3 Event-Related Potential is related to Brain Glutamine/Glutamate Ratio MeasuredIn Vivo, 2015-02-14

• Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization, 2022-10-07

• A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults, 2017-09-08

• Genetic architecture of subcortical brain structures in 38,851 individuals, 2019-10-21

• Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report, 2013-06-19

• The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder And Amygdala Structure And Function, 2014-01-18

• The Use of Electronic Health Records for Psychiatric Phenotyping and Genomics, 2017-05-30

• Genome-wide association study of depressive symptoms in the Hispanic Community Health Study/Study of Latinos, 2017-12-16

• Extending the ‘cross-disorder' relevance of executive functions to dimensional neuropsychiatric traits in youth, 2015-09-28

• Glycobiology and schizophrenia: A biological hypothesis emerging from genomic research, 2020-05-06

• Genetic determinants of depression: Recent findings and future directions, 2014-12-30

• Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies, 2018-03-01

• Genetic associations with suicide attempt severity and genetic overlap with major depression, 2019-01-17

• The effect of ADHD candidate gene polymorphisms on the course of ADHD, 2009-11-10

• Screening pregnant women for suicidal behavior in electronic medical records: diagnostic codes vs. clinical notes processed by natural language processing, 2018-05-29

• Mental health predicts better academic outcomes: A longitudinal study of elementary school students in Chile, 2015-05-15

• Low depression frequency is associated with decreased risk of cardiometabolic disease, 2022-02-14

• Greater Neurobiological Resilience to Chronic Socioeconomic or Environmental Stressors Associates With Lower Risk for Cardiovascular Disease Events, 2020-08-13

• Implementation of Electronic Consent at a Biobank: An Opportunity for Precision Medicine Research, 2016-06-09

• Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry, 2019-10-07

• ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide, 2015-12-04

• Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection, 2021-06-07

• Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures, 2015-07-07

• Collaborative genome-wide association analysis supports a role forANK3andCACNA1Cin bipolar disorder, 2009-06-25

• Biochemical, physiologic, and clinical effects of L-methylfolate in schizophrenia: A randomized controlled trial, 2017-03-14

• Increase in Suicidal Thinking During COVID-19, 2021-03-15

• Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations, 2022-06-29

• Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain, 2021-09-16

• Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women's Health Initiative Memory Study, 2014-09-08

• Geographic Variation in Obesity at the State Level in the All of Us Research Program, 2021-12-23

• Genomewide Association Analyses of Electrophysiological Endophenotypes for Schizophrenia and Psychotic Bipolar Disorders: A Preliminary Report, 2015-03-04

• Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders, 2022-06-14

• Largest GWAS of PTSD (N=20,070) Yields Genetic Overlap with Schizophrenia and Sex Differences in Heritability, 2017-04-25

• Using Life History Calendars to Improve Measurement of Lifetime Experience with Mental Disorders, 2019-03-11

• Genomewide Association Studies of Posttraumatic Stress Disorder in Two Cohorts of US Army Soldiers, 2016-07-01

• Investigating the relationship between depression and breast cancer: observational and genetic analyses, 2023-05-04

• Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics, 2021-01-08

• Why Many Geneticists and Psychological Scientists Have Discrepant Views About Gene-Environment Interaction (G×E) Research, 2020-08-14

• Translating Discoveries in Attention-Deficit/Hyperactivity Disorder Genomics to an Outpatient Child and Adolescent Psychiatric Cohort, 2020-08-01

• Limbic system white matter microstructure and long-term treatment outcome in major depressive disorder: A diffusion tensor imaging study using legacy data, 2012-04-30

• Genome-wide association study identifies 48 common genetic variants associated with handedness, 2020-09-28

• An eMERGE Clinical Center at Partners Personalized Medicine, 2016-01-20

• Polygenic prediction via Bayesian regression and continuous shrinkage priors, 2019-04-16

• Genome-wide association study of suicide attempt in psychiatric disorders identifies association with major depression polygenic risk scores, 2019-06-05

• Testing the Stability and Validity of an Executive Dysfunction Classification Using Task-Based Assessment in Children and Adolescents, 2020-12-17

• Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US Associations Between Genetic Risk for Adult Suicide Attempt and Suicidal Behaviors in Young Children in the US, 2022-08-31

• COMTVal158Met genotype is associated with reward learning: A replication study and meta-analysis, 2016-04-19

• Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease, 2021-01-13

• The genetic architecture of the human cerebral cortex, 2020-03-20

• Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years, 2021-02-11