Dr. George Daley, MD

• Hematology

• Internal Medicine

*Healthgrades does not verify qualifications for medical specialties. Please verify your provider's specialty and qualifications directly with your provider and applicable medical board.

• Brigham And Women's/children's

  Fellowship Hospital

• Mass General Hospital

  Residency Hospital

• Harvard Medical School

  Medical School, 1991

• Massachusetts Institute Of Technology, Phd

  1989

• Harvard University

  Undergraduate School, 1982

• Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production, 2016-10-04

• Raman microspectroscopy reveals unsaturation heterogeneity at the lipid droplet level and validates anin vitromodel of bone marrow adipocyte subtypes, 2022-11-23

• Lin28atransgenic mice manifest size and puberty phenotypes identified in human genetic association studies, 2010-05-30

• A systems biology pipeline identifies regulatory networks for stem cell engineering, 2019-07-01

• Euchromatin islands in large heterochromatin domains are enriched for CTCF binding and differentially DNA-methylated regions, 2012-10-26

• Deconstructing transcriptional heterogeneity in pluripotent stem cells, 2014-12-04

• The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming, 2014-10-11

• Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity, 2011-09-11

• LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells, 2021-07-31

• Reprogramming of T Cells from Human Peripheral Blood, 2010-07-02

• Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal, 2012-11-02

• Alternative Splicing of MBD2 Supports Self-Renewal in Human Pluripotent Stem Cells, 2014-05-08

• Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells, 2009-06-18

• Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells, 2011-02-04

• Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis, 2022-04-05

• Reconstruction of complex single-cell trajectories using CellRouter, 2018-03-01

• A comprehensive methylome map of lineage commitment from hematopoietic progenitors, 2010-08-15

• Targeting wild-type and T315I Bcr-Abl by combining allosteric with ATP-site inhibitors, 2010-01-13

• Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells, 2011-11-27

• Use of Differentiated Pluripotent Stem Cells in Replacement Therapy for Treating Disease, 2014-08-22

• Influence of Threonine Metabolism on S-adenosyl-methionine and Histone Methylation, 2012-11-01

• Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28, 2018-06-05

• Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA, 2010-09-30

• Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons, 2023-06-26

• Somatic coding mutations in human induced pluripotent stem cells, 2011-03-03

• PRC2 is required to maintain expression of the maternalGtl2-Rian-Mirglocus by preventingde novoDNA methylation in mouse embryonic stem cells, 2015-08-20

• Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival, 2012-11-29

• CellNet: Network Biology Applied to Stem Cell Engineering, 2014-08-14

• Induced pluripotent stem cells with a pathological mitochondrial DNA deletion, 2013-03-05

• Drug discovery for Diamond-Blackfan anemia using reprogrammed hematopoietic progenitors, 2017-02-08

• Comment on "Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells”, 2013-06-05

• Dynamic instability of genomic methylation patterns in pluripotent stem cells, 2010-09-24

• Induced Pluripotent Stem Cells for Neural Tissue Engineering, 2011-04-22

• Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients, 2010-02-17

• Hematopoietic Development from Human Induced Pluripotent Stem Cells, 2010-03-11

• Regulation of haematopoietic multipotency by EZH1, 2018-01-17

• All-Trans Retinoic Acid Directs Urothelial Specification of Murine Embryonic Stem Cells via GATA4/6 Signaling Mechanisms, 2010-07-13

• Interactions betweenCdxgenes and retinoic acid modulate early cardiogenesis, 2011-04-03

• Accessing naive human pluripotency, 2012-03-29

• Targeted and genome-scale methylomics reveals gene body signatures in human cell lines, 2009-03-29

• Lin28bis sufficient to drive liver cancer and necessary for its maintenance in murine models, 2014-08-11

• A comparison of non-integrating reprogramming methods, 2014-12-01

• Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target, 2020-07-03

• Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart, 2011-12-08

• Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells, 2015-09-10

• Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration, 2009-03-20

• Lin28 Enhances Tumorigenesis and is Associated With Advanced Human Malignancies, 2009-05-31

• Lin28 andlet-7regulate the timing of cessation of murine nephrogenesis, 2019-01-11

• Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells, 2011-05-08

• Excision of a viral reprogramming cassette by delivery of syntheticCremRNA, 2012-06-05

• Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway, 2012-03-13

• The role of Lin28b in myeloid and mast cell differentiation and mast cell malignancy, 2015-02-06

• Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism, 2013-07-11

• A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells, 2009-11-13

• Lin28 paralogs regulate lung branching morphogenesis, 2021-07-20

• Hypoxic, glycolytic metabolism is a vulnerability of B-acute lymphoblastic leukemia-initiating cells, 2022-04-26

• Activation of tyrosine kinases by mutation of the gatekeeper threonine, 2008-09-14

• Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity, 2016-12-20

• New lessons learned from disease modeling with induced Pluripotent Stem Cells, 2012-06-28

• Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice, 2011-04-29

• Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration, 2011-10-28

• Sex-specific regulation of weight and puberty by the Lin28/let-7 axis, 2015-12-23

• Dissecting engineered cell types and enhancing cell fate conversion via CellNet, 2014-08-14

• Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via re-specification of lineage-restricted precursors, 2013-10-03

• Lin28aregulates germ cell pool size and fertility, 2013-04-22

• Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells, 2012-10-28

• Biomechanical forces promote embryonic haematopoiesis, 2009-05-13

• A prudent path forward for genomic engineering and germline gene modification, 2015-03-19

• Lin28enhances tissue repair by reprogramming cellular metabolism, 2013-11-07

• Hematopoietic Defects and iPSC Disease Modeling: Lessons Learned, 2013-09-25

• The promise of induced pluripotent stem cells in research and therapy, 2012-01-18

• Author Correction: Lin28 andlet-7regulate the timing of cessation of murine nephrogenesis, 2020-03-09

• Down syndrome suppression of tumor growth and the role of the calcineurin inhibitor DSCR1, 2009-05-20

• Disease-specific induced pluripotent stem (iPS) cells, 2008-08-07

• Caudal genes in blood development and leukemia, 2012-05-17

• Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment, 2009-06-10

• A role forLin28in primordial germ cell development and germ cell malignancy, 2009-07-05

• Metabolic regulation of inflammasome activity controls embryonic hematopoietic stem and progenitor cell production, 2020-08-17

• Chromatin modifying enzymes as modulators of reprogramming, 2012-03-04

• Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia, 2010-07-08

• The transcriptional landscape of hematopoietic stem cell ontogeny, 2012-11-02

• Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia, 2020-10-21

• A CLK3-HMGA2 alternative splicing axis impacts human hematopoietic stem cell molecular identity throughout development, 2018-04-05

• Human endogenous retrovirus K (HML-2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells, 2013-10-24

• microRNA Expression during Trophectoderm Specification, 2009-07-03

• Functional Evidence that the Self-Renewal GeneNANOGRegulates Human Tumor Development, 2012-03-30

• Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting, 2020-09-22

• Haematopoietic stem and progenitor cells from human pluripotent stem cells, 2017-05-17

• EZH1 repression generates mature iPSC-derived CAR T cells with enhanced antitumor activity, 2022-08-04

• YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow, 2020-02-06

• Engineering Hematopoietic Stem Cells: Lessons from Development, 2016-06-02

• Metabolic Regulation of Protein N-alpha-acetylation by Bcl-xL Promotes Cell Survival, 2011-08-19

• Differential modeling of Fragile X syndrome by human embryonic stem cells and induced-pluripotent stem cells, 2010-05-07

• Pluripotent stem cell models of Shwachman-Diamond syndrome reveal a common mechanism for pancreatic and hematopoietic dysfunction, 2013-04-18

• Induced Pluripotent Stem Cells: A novel frontier in the study of human primary immunodeficiencies, 2010-12-24

• rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin, 2021-11-09

• Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming, 2009-03-29

• Multiple mechanisms disrupt thelet-7microRNA family in neuroblastoma, 2016-07-14

• CellComm infers cellular crosstalk that drives haematopoietic stem and progenitor cell development, 2022-04-12

• Genomic Approaches to Deconstruct Pluripotency, 2011-09-22

• Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts, 2009-11-01

• LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency, 2016-12-19

• TheLIN28B/let-7axis is a novel therapeutic pathway in Multiple Myeloma, 2016-10-24

• Comprehensive mapping of pluripotent stem cell metabolism using dynamic genome-scale network modeling, 2017-12-05

• Effect of developmental stage of HSC and recipient on transplant outcomes, 2014-06-09

• TheLin28/let-7axis regulates glucose metabolism, 2011-09-30

• Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells, 2010-11-07

• Integrative analyses of human reprogramming reveal dynamic nature of induced pluripotency, 2015-07-16

• Epoxyeicosatrienoic Acids Enhance Embryonic Haematopoiesis and Adult Marrow Engraftment, 2015-07-23

• Oncogenic switch and single-agent MET inhibitor sensitivity in a subset ofEGFR-mutant lung cancer, 2021-09-01