Dr. David Margolis, MD

• Infectious Disease Medicine

• Internal Medicine

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• Tufts University

  Medical School, 1985

• Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection, 2020-03-20

• The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation, 2019-10-09

• Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay, 2020-08-06

• Polyclonal B Cell Differentiation and Loss of Gastrointestinal Tract Germinal Centers in the Earliest Stages of HIV-1 Infection, 2009-07-07

• SARS-CoV-2 D614G Variant Exhibits Efficient Replicationex vivoand Transmissionin vivo, 2020-11-12

• The HIV-1 latent reservoir is largely sensitive to circulating T cells, 2020-10-06

• Characterizing the switching thresholds of magnetophoretic transistors, 2015-09-09

• Brain microglia serve as a persistent HIV reservoir despite durable antiretroviral therapy, 2023-06-15

• Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency, 2018-10-02

• AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques, 2023-10-02

• Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency, 2014-03-10

• Curing HIV: Seeking to target and clear persistent infection, 2020-03-26

• The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial, 2010-08-10

• Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection, 2016-10-07

• Framing expectations in early HIV cure research, 2014-10-09

• Cellular Gene Modulation of HIV-Infected CD4 T Cells in Response to Serial Treatment with the Histone Deacetylase Inhibitor Vorinostat Maxwell et al., 2020-06-16

• Combined approaches for HIV cure, 2014-03-13

• Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170), 2012-07-17

• Elimination of SHIV Infected Cells by Combinations of Bispecific HIVxCD3 DART®Molecules, 2021-08-13

• No Effect of Raltegravir Intensification on Viral Replication Markers in the Blood of HIV-1-infected Patients Receiving Antiretroviral Therapy, 2012-03-01

• An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients, 2013-12-26

• Latency reversal and viral clearance to cure HIV-1, 2016-07-22

• Therapy for Persistent HI, 2010-03-05

• New Concepts in Therapeutic Manipulation of HIV-1 Transcription and Latency: Latency Reversal versus Latency Prevention, 2023-07-31

• Predictors of Residual Viremia in Patients on Long-term Suppressive Antiretroviral Therapy, 2012-08-22

• Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency, 2015-09-04

• Improved Measures of Quality of Life, Lipid Profile and Lipoatrophy after Treatment Interruption in HIV-Infected Patients with Immune Preservation: results of ACTG 5170, 2008-12-01

• Microglia-Specific Promoter Activities ofHEXBGene, 2022-03-10

• SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo, 2020-11-12

• Efficacy of NNRTI-Based Antiretroviral Therapy Initiated During Acute HIV Infection, 2011-04-24

• Translational Challenges in Targeting Latent HIV infection and the CNS reservoir problem, 2014-07-25

• Detection of Human Immunodeficiency Virus RNAs in living cells using Spinach RNA aptamers, 2016-11-30

• Gold nanoparticles to improve HIV drug delivery, 2015-07-09

• Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA, 2021-02-24

• Systemic HIV and SIV latency reversal via non-canonical NF-?B signallingin vivo, 2020-01-22

• Regimen Simplification to Atazanavir-Ritonavir Alone as Maintenance Antiretroviral Therapy: Final 48-Week Clinical and Virologic Outcomes, 2009-03-15

• Dose-Responsive Gene Expression in Suberoylanilide Hydroxamic Acid (SAHA) Treated Resting CD4+ T Cells, 2015-09-02

• 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity, 2022-05-11

• Evaluation of a COVID-19 convalescent plasma program at a U.S. academic medical center, 2022-12-08

• Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors, 2021-02-26

• Detection of Nonnucleoside Reverse-Transcriptase Inhibitor-Resistant HIV-1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy, 2008-08-01

• Outcomes of Convalescent Plasma with Defined High versus Lower Neutralizing Antibody Titers against SARS-CoV-2 among Hospitalized Patients: CoronaVirus Inactivating Plasma (CoVIP) Study, 2022-09-22

• Sex Disparities and Neutralizing-Antibody Durability to SARS-CoV-2 Infection in Convalescent Individuals, 2021-08-25

• New Frontiers in Measuring and Characterizing the HIV Reservoir, 2019-12-18

• Degradation of Polycomb Repressive Complex 2 with an EED-targeted Bivalent Chemical Degrader, 2019-12-09

• Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection, 2014-08-19

• Eradicating HIV-1 infection: seeking to clear a persistent pathogen, 2015-03-24

• Therapy for latent human immunodeficiency virus type 1 infection: the role of histone deacetylase inhibitors, 2014-01-29

• Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP, 2022-03-22

• Combined noncanonical NF-?B agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo, 2022-04-15

• Four Weeks of Treatment With Rifaximin Fails to Significantly Alter Microbial Diversity in Rectal Samples of HIV-Infected Immune Non-Responders (ACTG A5286) Which May be Attributed to Rectal Swab Use, 2019-09-23

• A Cure for HIV Infection: "Not in My Lifetime” or "Just Around the Corner”?, 2016-08-17

• Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors, 2009-09-10