Dr. David Boulware, MD

• Infectious Disease Medicine

• Tropical Medicine

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• Masters Of Public Health, University Of Minnesota

  2007

• University Of Minnesota

  Fellowship Hospital, 2007

• Certificate Of Clinical Tropical Medicine And Travelers Health

  2006

• University Of Minnesota / Twin Cities Campus

  Internship Hospital, 2001

• Indiana University School Of Medicine

  Medical School, 2000

• Wabash College

  Undergraduate School, 1996

• Pharmacokinetics-Pharmacodynamics of Sertraline as an Antifungal in HIV-Infected Ugandans with Cryptococcal Meningitis, 2019-10-04

• Rates of refusal of clinical autopsies among HIV-positive decedents and an overview of autopsies in Uganda [version 2; peer review: 4 approved], 2022-02-01

• Paucity of Initial Cerebrospinal Fluid Inflammation in Cryptococcal Meningitis is associated with subsequent Immune Reconstitution Inflammatory Syndrome, 2010-09-15

• B Cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis Okurut et al., 2020-02-20

• Cryptococcus-Related Immune Reconstitution Inflammatory Syndrome(IRIS): Pathogenesis and Its Clinical Implications, 2011-12-01

• Diagnostic Performance of a Multiplex PCR assay for meningitis in an HIV-infected population in Uganda, 2015-12-01

• Standardized Urine-Based Tuberculosis (TB) Screening With TB-Lipoarabinomannan and Xpert MTB/RIF Ultra in Ugandan Adults With Advanced Human Immunodeficiency Virus Disease and Suspected Meningitis, 2020-03-24

• Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-infected individuals with CD4 <100 cells/µL: a stepped-wedge, cluster-randomized trial, 2019-02-01

• Should we perform the serum cryptococcal antigen test in people living with HIV/AIDS hospitalized due to a community-acquired pneumonia episode?, 2020-02-23

• The Immunopathogenesis of Cryptococcal Immune Reconstitution Inflammatory Syndrome - Understanding a Conundrum, 2015-11-19

• Virologic monitoring can be a cost-effective strategy to diagnose treatment failure on first-line ART, 2016-04-01

• Integrating Cryptococcal Antigen Screening and Preemptive Treatment into Routine HIV care, 2012-04-15

• ATI-2307 Exhibits Equivalent Antifungal Activity inCryptococcus neoformansClinical Isolates With High and Low Fluconazole IC50, 2021-06-23

• Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: a comparison of three prospective cohorts, 2017-06-12

• Phase I EnACT Trial of the Safety and Tolerability of a Novel Oral Formulation of Amphotericin B Skipper et al., 2020-09-21

• Poor specificity of urinary cryptococcal antigen testing (Reply to Drainet al.Prevalence of cryptococcal antigenuria at initial HIV diagnosis in KwaZulu-Natal), 2015-09-07

• Host Directed Therapies for Tuberculous Meningitis [version 2; peer review: 2 approved], 2021-07-01

• Cryptococcal Meningoencephalitis Relapse after an 8 Year Delay: An Interplay of Infection and Immune Reconstitution?, 2014-12-12

• Early Treatment with Fluvoxamine among Patients with COVID-19: A Cost-Consequence Model, 2022-11-15

• EVALUATION OF THE BIOFIRE FILMARRAY MENINGITIS/ENCEPHALITIS PANEL IN AND ADULT AND PEDIATRIC UGANDAN POPULATION, 2021-06-24

• Cytomegalovirus viremia as a risk factor for mortality in HIV-associated cryptococcal and tuberculous meningitis, 2022-07-16

• Improved Influenza Diagnostics through Thermal Contrast Amplification, 2021-03-07

• Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis, 2022-03-24

• Prevalence ofHistoplasmaAntigenuria among Outpatient Cohort with Advanced HIV in Kampala, Uganda, 2023-07-18

• Long Term 5-Year Survival of Persons with Cryptococcal Meningitis or Asymptomatic Subclinical Antigenemia in Uganda, 2012-12-10

• Landmark Clinical Observations and Immunopathogenesis Pathways Linked to HIV andCryptococcusFatal Central Nervous System Co-infection, 2020-06-19

• Cellular Immune Activation in Cerebrospinal Fluid From Ugandans With Cryptococcal Meningitis and Immune Reconstitution Inflammatory Syndrome, 2014-12-09

• Serum Cryptococcal Antigen (CRAG) Screening is a Cost-Effective Method to Prevent Death in HIV- infected persons with CD4 =100/µL starting HIV therapy in Resource-Limited Settings, 2010-08-15

• The Role of Nanoparticle Design in Determining Analytical Performance of Lateral Flow Immunoassays, 2017-11-15

• Antiretroviral Therapy Down-regulates Innate Antiviral Response Genes in Patients with AIDS in Sub-Saharan Africa, 2010-12-01

• Tuberculosis in HIV-infected Ugandan Children starting on Antiretroviral Therapy, 2012-04-02

• High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial, 2021-03-08

• Transcriptomic biomarker pathways associated with death in HIV-infected patients with cryptococcal meningitis, 2021-04-16

• Seroprevalence of Histoplasmosis in Somali, Burmese, and Hmong Refugees Residing in Thailand and Kenya, 2017-11-08

• Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in Tanzania, 2019-02-01

• Cerebrospinal fluid AFB smear in adults with tuberculous meningitis: a systematic review and diagnostic test accuracy meta-analysis, 2022-06-24

• Socioeconomic position and ten-year survival and virologic outcomes in a Ugandan HIV cohort receiving antiretroviral therapy, 2017-12-15

• Seroprevalence of histoplasmosis in Kampala, Uganda, 2015-11-02

• Utility of the Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis, 2013-10-22

• Monocyte Phenotype and IFN-?-Inducible Cytokine Responses Are Associated with Cryptococcal Immune Reconstitution Inflammatory Syndrome, 2017-06-02

• AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial, 2018-11-23

• Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies [version 2; peer review: 2 approved], 2020-06-03

• Pediatric HIV Immune Reconstitution Inflammatory Syndrome (IRIS), 2009-03-24

• Performance of Cryptococcal Antigen Lateral Flow Assay Using Saliva in Ugandans with CD4 <100, 2014-07-31

• Accuracy of Pima point-of-care CD4 analyzer in routine use in public health clinics in Uganda, 2013-07-01

• Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection [version 2; referees: 2 approved], 2019-01-15

• "There are many fevers”: Communities' perception and management of Febrile illness and its relationship with human animal interactions in South-Western Uganda, 2022-02-22

• Comparison of Cryptococcal Antigenemia between Antiretroviral Naive and Antiretroviral Experienced HIV Positive Patients at Two Hospitals in Ethiopia, 2013-10-04

• Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis, 2020-10-29

• Safety, Censoring, and Intent-to-treat: Dangers to Generalizability, 2010-10-15

• Longitudinal Changes in CD4+, CD8+T Cell Phenotype and Activation Marker Expression Following Antiretroviral Therapy Initiation among Patients with Cryptococcal Meningitis, 2019-07-17

• Short course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania, 2019-10-21

• Effects of tenofovir and amphotericin B deoxycholate co-administration on kidney function in patients treated for cryptococcal meningitis, 2016-01-01

• Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection, 2015-03-12

• Prevalence and nature of potential drug-drug interactions among hospitalized HIV patients presenting with suspected meningitis in Uganda, 2020-08-05

• Cerebrospinal Fluid Bacillary Load by Xpert MTB/RIF Ultra Polymerase Chain Reaction Cycle Threshold Value Predicts 2-Week Mortality in Human Immunodeficiency Virus-Associated Tuberculous Meningitis, 2020-09-28

• Sterile Cerebrospinal Fluid Culture at Cryptococcal Meningitis Diagnosis Is Associated with High Mortality, 2022-12-28

• Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma,anti-Coccidioides,and anti-Blastomycesantibodies, 2019-01-01

• Central Nervous System Immune Reconstitution Inflammatory Syndrome, 2013-12-27

• Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality, 2018-12-31

• Reflexive Laboratory-Based Cryptococcal Antigen Screening and Preemptive Fluconazole Therapy for Cryptococcal Antigenemia in HIV-Infected Individuals With CD4 <100 Cells/µL: A Stepped-Wedge, Cluster-Randomized Trial, 2018-11-05

• Prevalence of Contraindications to Nirmatrelvir-Ritonavir Among Hospitalized Patients With COVID-19 at Risk for Progression to Severe Disease Prevalence of Contraindications to Nirmatrelvir-Ritonavir Among Patients With COVID-19, 2022-11-15

• Efficacy of Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis: an open-label dose-ranging study, 2016-03-10

• Methods of rapid diagnosis for the etiology of meningitis in adults, 2014-11-15

• Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America, 2013-05-10

• Tuberculosis in HIV-Associated Cryptococcal Meningitis is Associated with an Increased Risk of Death, 2020-03-13

• Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial, 2019-01-14

• Detection ofMycobacterium tuberculosisin urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis, 2018-10-01

• High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) [version 2; peer review: 2 approved], 2020-08-25

• Flow Cytometry To Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis Scriven et al., 2016-02-25

• Xpert Ultra's place in the diagnosis of tuberculous meningitis - Authors' reply, 2019-01-09

• Are fluconazole or sertraline dose adjustments necessary with concomitant rifampin?, 2017-08-01

• Cerebrospinal Fluid Biomarkers and HIV-Associated Neurocognitive Disorders in HIV- Infected Individuals in Rakai, Uganda, 2016-12-19

• Cryptococcal meningitis: A neglected NTD?, 2017-06-29

• Tuberculous meningitis diagnosis and outcomes during the Xpert MTB/Rif era: a 6.5-year cohort study in Uganda [version 2; referees: 3 approved], 2018-07-03

• Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study, 2018-01-01

• Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: a prospective cohort study, 2019-06-26

• HIV-Associated Cryptococcal Immune Reconstitution Inflammatory Syndrome Is Associated with Aberrant T Cell Function and Increased Cytokine Responses, 2019-05-23

• Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial, 2023-03-05

• Recent advances in AIDS-related cryptococcal meningitis treatment with an emphasis on resource limited settings, 2017-02-09

• Acridine orange fluorescent microscopy is more sensitive than India ink light microscopy in the rapid detection of cryptococcosis among CrAg positive HIV patients, 2017-07-27

• Cryptococcus neoformansEx Vivo Capsule Size Is Associated With Intracranial Pressure and Host Immune Response in HIV-associated Cryptococcal Meningitis, 2013-08-14

• Cost-effective Diagnostic Checklists for Meningitis in Resource Limited Settings, 2013-07-01

• Impact of nurse-targeted care on HIV outcomes among immunocompromised persons: a before-after study in Uganda, 2016-06-01

• Cryptococcal Immune Reconstitution Inflammatory Syndrome in HIV-1-infected individuals: Literature Review and Proposed Clinical Case Definitions, 2011-01-11

• Superior Diagnostic Performance of Malaria Rapid Diagnostic Tests as compared to Blood Smears in U.S. Clinical Practice, 2009-09-15

• Role of Quantitative CSF Microscopy to Predict Culture Status and Outcome in HIV-Associated Cryptococcal Meningitis in a Brazilian Cohort, 2012-02-23

• Hookworm infection is associated with decreased CD4+T cell counts in HIV-infected adult Ugandans, 2017-05-25

• Sex-specific associations between cerebrospinal fluid inflammatory marker levels and cognitive function in antiretroviral treated people living with HIV in rural Uganda, 2020-12-24

• Heterogeneity in neurocognitive change trajectories among people with HIV starting antiretroviral therapy in Rakai, Uganda, 2019-06-19

• The clinical pattern, prevalence, and factors associated with immune reconstitution inflammatory syndrome in Ugandan children, 2010-08-24

• Epidemiology of non-traumatic spinal cord injury in Uganda: a single center, prospective study with MRI evaluation, 2019-01-15

• Diagnostic accuracy of Xpert MTB/RIF for tuberculous meningitis: a systematic review and meta-analysis, 2020-11-30

• Identification of Pathogen Genomic Differences That Impact Human Immune Response and Disease during Cryptococcus neoformans Infection Gerstein et al., 2019-07-16

• Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study, 2020-03-01

• Prognostic Implications of Baseline Anemia and Changes in Hemoglobin Concentrations with Amphotericin B therapy for Cryptococcal Meningitis, 2016-04-28

• A Glucuronoxylomannan-Associated Immune Signature, Characterized by Monocyte Deactivation and an Increased Interleukin 10 Level, Is a Predictor of Death in Cryptococcal Meningitis, 2016-01-14

• Reproducibility of CSF Quantitative Culture Methods for Estimating Rate of Clearance in Cryptococcal Meningitis, 2016-01-14

• Early ART After Cryptococcal Meningitis Is Associated With Cerebrospinal Fluid Pleocytosis and Macrophage Activation in a Multisite Randomized Trial, 2015-02-04

• Performance of Lipoarabinomannan Assay using Cerebrospinal fluid for the diagnosis of Tuberculous meningitis among HIV patients [version 2; peer review: 2 approved], 2019-09-30

• Clinical Features and Serum Biomarkers in HIV Immune Reconstitution Inflammatory Syndrome after Cryptococcal Meningitis: A Prospective Cohort Study, 2010-12-21

• Predictors of Neurocognitive Outcomes on Antiretroviral Therapy after Cryptococcal Meningitis: A prospective cohort study, 2014-01-09

• Systematic Review of Interventions for Depression for People Living with HIV in Africa, 2018-02-16

• Nurse-targeted care for HIV positive persons with CD4<100 improved time to ART initiation and retention in Uganda, 2015-08-20

• Adherence of health workers to guidelines for screening and management of cryptococcal meningitis in Uganda, 2023-04-10

• Improved Diagnostic Sensitivity for TB Meningitis with Xpert MTB/Rif of centrifuged CSF: a prospective study, 2016-02-24

• High dose oral and intravenous rifampicin for improved survival from adult tuberculous meningitis: a phase II open-label randomised controlled trial (the RifT study) [version 1; referees: 2 approved], 2018-07-10

• Xpert MTB/RIF Ultra for Tuberculosis Testing in Children: A Mini-Review and Commentary, 2019-02-28

• Towards a scalable HIV cure research agenda: the role of co-infections, 2015-09-24

• A Systematic Review of Non-Traumatic Spinal Cord Injuries in Sub-Saharan Africa and a Proposed Diagnostic Algorithm for Resource-Limited Settings, 2017-12-08

• The CSF immune response in HIV-1-associated cryptococcal meningitis: macrophage activation, correlates of disease severity and effect of antiretroviral therapy, 2017-07-01

• Improvement in depressive symptoms after antiretroviral therapy initiation in people with HIV in Rakai, Uganda, 2021-07-31

• Impact of community engagement and social support on the outcomes of HIV-related meningitis clinical trials in a resource-limited setting, 2020-08-20

• LeptospiraSeroprevalence and Risk Factors in Health Centre Patients in Hoima District, Western Uganda, 2016-08-03

• Adjunctive sertraline in HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial, 2020-02-19

• Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis, 2019-07-10

• Cryptococcal Antigenemia in Human Immunodeficiency Virus Antiretroviral Therapy-Experienced Ugandans With Virologic Failure, 2019-11-03

• It is Possible to Differentiate Tuberculous and Cryptococcal Meningitis in HIV-infected Patients Using Only Clinical and Basic Cerebrospinal Fluid Characteristics?, 2017-01-30

• Treatment Outcomes in Adult Tuberculous Meningitis: A Systematic Review and Meta-analysis, 2020-06-30

• Diagnosis and Management of Cryptococcal Relapse, 2013-04-29

• Authors reply: Fluconazole Pharmacokinetics in Human Cryptococcal Meningitis, 2016-09-19

• Xpert MTB/Rif Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation, 2020-01-07

• Ophthalmic signs in Ugandan adults with HIV-associated cryptococcal meningitis: A nested analysis of the ASTRO-CM cohort [version 2; referees: 2 approved], 2018-10-12

• Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis, 2012-09-25

• Evaluation of a national cryptococcal antigen screening program for HIV-infected patients in Uganda: A cost-effectiveness modeling analysis, 2019-01-10

• Disseminated Cryptococcosis Is a Common Finding among Human Immunodeficiency Virus-Infected Patients with Suspected Sepsis and Is Associated with Higher Mortality Rates, 2023-08-09

• Cryptococcal Meningitis: Diagnosis and Management Update, 2015-04-22

• Ending deaths from HIV-related cryptococcal meningitis by 2030, 2020-11-30

• Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization A Systematic Review and Meta-analysis Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization, 2022-04-06

• Absence of Cerebrospinal Fluid Pleocytosis in Tuberculous Meningitis is a Common Occurrence in HIV Co-infection and a Predictor of Poor Outcomes, 2018-01-31

• Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward, 2020-06-16

• Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2: Support for the FIASMA Model against COVID-19, 2022-10-05

• Evaluation of a point-of-care immunoassay test kit ‘StrongStep' for cryptococcal antigen detection, 2018-01-05

• Neurocognitive outcomes of tuberculous meningitis in a primarily HIV-positive Ugandan cohort [version 2; peer review: 1 approved, 2 approved with reservations], 2022-03-03