Dr. Cynthia Sears, MD

• Infectious Disease Medicine

• Internal Medicine

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• Thomas Jefferson University

  Medical School, 1977

• Intestinal Microbiota-Produced Trimethylamine-N-oxide and its Association with Coronary Stenosis and HIV Serostatus, 2016-05-01

• Bacterial-driven inflammation and mutantBRAFexpression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy, 2021-02-25

• Human Colon Cancer-DerivedClostridioides difficileStrains Drive Colonic Tumorigenesis in Mice, 2022-06-09

• Microbes, Microbiota and Colon Cancer, 2014-03-12

• Stat3 Activation in Murine Colitis Induced by EnterotoxigenicBacteroides fragilis, 2014-06-14

• Regulatory T cell response to enterotoxigenicBacteroides fragiliscolonization triggers IL-17-dependent colon carcinogenesis, 2015-07-22

• Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer, 2018-09-13

• Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps, 2021-05-04

• Microbiota and Immune Responses in Colon Cancer More to Learn, 2016-03-05

• Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1 and Polycomb Members to Promoter CpG Islands, 2011-11-15

• Bacterial genotoxin accelerates transient infection-driven murine colon tumorigenesis, 2021-09-03

• Western-style Diet,pksIsland-CarryingEscherichia coli, and Colorectal Cancer: Analyses from Two Large Prospective Cohort Studies, 2022-06-24

• IMMUNOPATHOLOGIC STRATIFICATION OF COLORECTAL CANCER FOR CHECKPOINT BLOCKADE IMMUNOTHERAPY, 2019-08-22

• A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses, 2009-08-23

• Gut colonization with an obesity-associated enteropathogenic microbe modulates the premetastatic niches to promote breast cancer lung and liver metastasis, 2023-07-12

• The Cancer Microbiome: Recent Highlights and Knowledge Gaps, 2021-08-16

• Adult-Attained Height and Colorectal Cancer Risk: A Cohort Study, Systematic Review and Meta-Analysis, 2022-04-01

• BACTEROIDES FRAGILISTOXIN COORDINATES A PRO-CARCINOGENIC INFLAMMATORY CASCADE VIA TARGETING OF COLONIC EPITHELIAL CELLS, 2018-02-01

• Impact of the gut microbiome on the genome and epigenome of colon epithelial cells: contributions to colorectal cancer development, 2019-02-25

• Microbiota Dysbiosis in Select Human Cancers: Evidence of Association and Causality, 2017-08-16

• Diet-Related and Gut-Derived Metabolites and Health Outcomes: A Scoping Review, 2022-12-14

• INTRATUMORAL ADAPTIVE IMMUNOSUPPRESSION AND TYPE 17 IMMUNITY IN MISMATCH REPAIR PROFICIENT COLORECTAL TUMORS, 2019-05-06

• The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints, 2014-10-30

• Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes, 2019-08-08

• Intestinal Bacteria Maintain Adult Enteric Nervous System and Nitrergic Neurons via Toll-like Receptor 2-induced Neurogenesis in Mice, 2020-03-29

• Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin, 2019-10-25

• Clostridium difficile in a HIV-Infected Cohort: Incidence, Risk Factors, and Clinical Outcomes, 2013-11-13

• Human colon cancer-derivedClostridioides difficilestrains drive colonic tumorigenesis in mice, 2022-08-05

• EnterotoxigenicBacteroides fragilis(ETBF)-mediated colitis in Min (Apc+/-) mice A human commensal-based murine model of colon carcinogenesis, 2010-01-18

• Yogurt consumption and colorectal polyps, 2020-02-20

• Author Correction: High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia, 2019-01-09

• 1001. Chronic Colonization with ToxigenicClostridioides difficileStrains Drives Colonic Tumorigenesis in Mice, 2021-12-04

• G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenicBacteroides fragilis, 2021-05-14

• Next-generation sequencing: insights to advance clinical investigations of the microbiome, 2022-04-01

• Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps, 2021-12-14

• Host Responses to Mucosal Biofilms in the Lung and Gut, 2020-02-28

• Association of EnterotoxigenicBacteroides fragilisInfection with Inflammatory Diarrhea, 2008-09-15

• Bacterial oncogenesis in the colon, 2013-09-10

• A shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia, 2011-10-21

• High-resolution bacterial 16S rRNA gene profile meta-analysis and biofilm status reveal common colorectal cancer consortia, 2017-11-29

• Glucosylceramide production maintains colon integrity in response toBacteroides fragilistoxin-induced colon epithelial cell signaling, 2020-10-13

• A uniform computational approach improved on existing pipelines to reveal microbiome biomarkers of non-response to immune checkpoint inhibitors, 2021-02-16

• Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms, 2020-09-24

• Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models, 2022-02-08

• Murine fecal microbiota transfer models selectively colonize human microbes and reveal transcriptional programs associated with response to neoadjuvant checkpoint inhibitors, 2022-02-26

• Non-toxigenicBacteroides fragilis(NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A, 2018-10-02

• Redundant innate and adaptive sources of IL-17 production drive colon tumorigenesis, 2016-02-15

• Antibody profiling of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses, 2022-05-31

• Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene, 2022-05-19