Dr. Alvin Powers Jr, MD

• Endocrinology, Diabetes & Metabolism

• Internal Medicine

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• University Of Tennessee College Of Medicine

  Medical School, 1979

• Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes, 2016-10-31

• Decreased pancreatic acinar cell number in type 1 diabetes, 2020-05-09

• Combinatorial transcription factor profiles predict mature and functional human isletaandßcells, 2021-09-22

• Non-Invasive Bioluminescence Imaging of ß-Cell Function in Obese-Hyperglycemic [ob/ob] Mice, 2014-09-08

• New-onset post-transplant diabetes mellitus after allogeneic hematopoietic cell transplant is initiated by insulin resistance, not immunosuppressive medications, 2019-02-07

• Standardized Transportation of Human Islets: An Islet Cell Resource Center Study of More Than 2,000 Shipments, 2012-08-10

• Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice, 2014-07-24

• Peeling the onion: another layer in the regulation of insulin secretion, 2023-04-17

• Enhanced expression of VEGF-A in ß cells increases endothelial cell number but impairs islet morphogenesis and ß cell proliferation, 2012-04-24

• Microtubules negatively regulate insulin secretion in pancreatic ß cells, 2015-09-28

• Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects, 2016-02-26

• Deep learning-based pancreas volume assessment in individuals with type 1 diabetes, 2022-01-05

• Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors, 2017-08-24

• aCell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals, 2022-06-01

• Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote ß cell regeneration, 2021-04-06

• Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes ß cell regeneration, 2014-02-20

• Pdx1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression, 2014-03-25

• Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring ß Cell Mass, 2021-08-06

• The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop, 2019-01-29

• A FEASIBLE APPROACH TO EVALUATE THE RELATIVE REACTIVITY OF NHS-ESTER ACTIVATED GROUP WITH PRIMARY AMINE-DERIVATIZED DNA ANALOGUE AND NON-DERIVATIZED IMPURITY, 2015-04-09

• Modeling monogenic diabetes using human ES cells reveals developmental and metabolic deficiencies caused by mutations in HNF1A, 2019-08-01

• Factor XI protein in human pancreas and kidney, 2009-03-04

• Signals in the pancreatic islet microenvironment influence ß cell proliferation, 2017-07-20

• Interrupted Glucagon Signaling Reveals Hepatic-a-Cell Axis and Role for L-Glutamine in a-Cell Proliferation, 2017-06-06

• Replicative capacity of ß-cells and type 1 diabetes, 2016-04-28

• Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes, 2016-07-08

• Glucagon receptor inactivation leads to a-cell hyperplasia in zebrafish, 2015-09-08

• Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings, 2022-10-01

• Development of a standardized MRI protocol for pancreas assessment in humans, 2021-08-24

• Age-dependent pancreatic gene regulation reveals mechanisms governing human ß-cell function, 2016-04-28

• Repeatability and Reproducibility of Pancreas Volume Measurements Using MRI, 2020-03-16

• Hyperglycemia-induced Proliferation of Adult Human Beta Cells Engrafted into Spontaneously Diabetic Immunodeficient NOD-Rag1nullIL2r?nullIns2AkitaMice, 2011-06-10

• Ectonucleoside triphosphate diphosphohydrolase-3 antibody targets adult human pancreatic ß-cells forin vitroandin vivoanalysis, 2018-11-15

• Endocrine Toxicities of Immune Checkpoint Inhibitors, 2021-04-19

• Quantitative Correlation of in Vivo Properties with in Vitro Assay Results: The in Vitro Binding of a Biotin-DNA Analogue Modifier with Streptavidin Predicts the in Vivo Avidin-Induced Clearability of the Analogue-Modified Antibody, 2015-07-08

• Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue, 2019-04-06

• Bioluminescence Imaging Reveals Dynamics of Beta Cell Loss in the Non-Obese Diabetic (NOD) Mouse Model, 2013-03-06

• Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice, 2019-09-05

• Hyperaminoacidemia induces pancreatic a cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways, 2023-01-16

• Humanized mice for the study of type 1 and type 2 diabetes, 2012-06-19

• Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion, 2016-02-12

• p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion, 2016-03-07

• Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions, 2018-12-14

• a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes, 2018-03-06

• Suppression of Insulin Production and Secretion by a Decretin Hormone, 2015-02-03

• Bioluminescence Imaging in Mouse Models Quantifies ß Cell Mass in the Pancreas and After Islet Transplantation, 2009-06-23

• Multiplexedin SituImaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes, 2019-01-31

• Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?, 2017-01-09